The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.

Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography / Mazzoccanti, G.; Manetto, S.; Bassan, M.; Foschini, A.; Orlandin, A.; Ricci, A.; Cabri, W.; Ismail, O. H.; Catani, M.; Cavazzini, A.; Gasparrini, F.. - In: RSC ADVANCES. - ISSN 2046-2069. - 10:21(2020), pp. 12604-12610. [10.1039/d0ra01296c]

Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

Mazzoccanti G.
Primo
;
Manetto S.;Gasparrini F.
Ultimo
2020

Abstract

The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.
2020
peptide epimers; UHPLC; dynamic electrostatic-repulsion reversed-phase
01 Pubblicazione su rivista::01a Articolo in rivista
Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography / Mazzoccanti, G.; Manetto, S.; Bassan, M.; Foschini, A.; Orlandin, A.; Ricci, A.; Cabri, W.; Ismail, O. H.; Catani, M.; Cavazzini, A.; Gasparrini, F.. - In: RSC ADVANCES. - ISSN 2046-2069. - 10:21(2020), pp. 12604-12610. [10.1039/d0ra01296c]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1391661
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