The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.
Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography / Mazzoccanti, G., Manetto, S., Bassan, M., Foschini, A., Orlandin, A., Ricci, A., Cabri, W., Ismail, O.H., Catani, M., Cavazzini, A., Gasparrini, F.. - In: RSC ADVANCES. - ISSN 2046-2069. - 10:21(2020), pp. 12604-12610. [10.1039/d0ra01296c]
Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
Mazzoccanti G.
Primo
;Manetto S.;Gasparrini F.
Ultimo
2020
Abstract
The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.| File | Dimensione | Formato | |
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