Purpose: Myopic foveoschisis (MF) is characterized by the splitting of the retinal layers in the fovea of patients with high myopia (HM). MF may progress into foveal detachment or macular hole formation with consequent loss of central vision. The aim of this study is to investigate morphological and functional changes of the macular region in myopic subjects with and without foveoschisis. Design: Observational, cross-sectional, comparative study. Methods: Forty-eight patients with HM and 24 healthy controls were evaluated by spectral domain-optical coherence tomography (SD-OCT), multifocal electroretinography (mfERG) and microperimetry (MP-1) tests to assess macular thickness, functionality and sensitivity values, respectively. The results of the diagnostic examinations were compared between three groups: HM patients with MF (N = 24), HM patients without MF (N = 24) and control group (CG) (N = 24). All statistical analyses were performed with STATA 14.0 (Collage Station, Texas, USA). One-way analysis of variance (ANOVA) followed by Tukey’s post hoc test was used to analyze differences between groups unless specified; p values < 0.05 were considered as statistically significant. Gender distribution was compared by the Chi square test. Results: The statistical analysis with one-way ANOVA followed by Tukey’s post hoc test showed a significant increase in macular thickness in HM patients with MF when compared to both HM patients without MF and CG. Morphological changes were associated with functional impairment as demonstrated by the significant decrease in amplitude of the P1 wave and MP-1 sensitivity (p < 0.05), according to the anatomical landmarks. Conclusions: This study showed that the morphological changes observed in the central retina of HM patients with MF are associated with functional alterations. High-tech diagnostic tests such as SD-OCT, mfERG and MP-1 could be useful for management in complications of MF. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

High myopic patients with and without foveoschisis: morphological and functional characteristics / Nebbioso, Marcella; Lambiase, A; Gharbiya, M; Bruscolini, A; Alisi, L; Bonfiglio, V.. - In: DOCUMENTA OPHTHALMOLOGICA. - ISSN 0012-4486. - 141:3(2020), pp. 227-236. [10.1007/s10633-020-09767-y]

High myopic patients with and without foveoschisis: morphological and functional characteristics

Marcella Nebbioso
Primo
Writing – Review & Editing
;
Lambiase A
Secondo
Data Curation
;
Gharbiya M
Visualization
;
Bruscolini A
Investigation
;
Alisi L
Penultimo
Formal Analysis
;
2020

Abstract

Purpose: Myopic foveoschisis (MF) is characterized by the splitting of the retinal layers in the fovea of patients with high myopia (HM). MF may progress into foveal detachment or macular hole formation with consequent loss of central vision. The aim of this study is to investigate morphological and functional changes of the macular region in myopic subjects with and without foveoschisis. Design: Observational, cross-sectional, comparative study. Methods: Forty-eight patients with HM and 24 healthy controls were evaluated by spectral domain-optical coherence tomography (SD-OCT), multifocal electroretinography (mfERG) and microperimetry (MP-1) tests to assess macular thickness, functionality and sensitivity values, respectively. The results of the diagnostic examinations were compared between three groups: HM patients with MF (N = 24), HM patients without MF (N = 24) and control group (CG) (N = 24). All statistical analyses were performed with STATA 14.0 (Collage Station, Texas, USA). One-way analysis of variance (ANOVA) followed by Tukey’s post hoc test was used to analyze differences between groups unless specified; p values < 0.05 were considered as statistically significant. Gender distribution was compared by the Chi square test. Results: The statistical analysis with one-way ANOVA followed by Tukey’s post hoc test showed a significant increase in macular thickness in HM patients with MF when compared to both HM patients without MF and CG. Morphological changes were associated with functional impairment as demonstrated by the significant decrease in amplitude of the P1 wave and MP-1 sensitivity (p < 0.05), according to the anatomical landmarks. Conclusions: This study showed that the morphological changes observed in the central retina of HM patients with MF are associated with functional alterations. High-tech diagnostic tests such as SD-OCT, mfERG and MP-1 could be useful for management in complications of MF. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
high myopia; microperimetry (MP-1); multifocal electroretinography (mfERG); myopic foveoschisis; pathological myopia; retinoschisis; spectral domain-optical coherence tomography (SD-OCT)
01 Pubblicazione su rivista::01a Articolo in rivista
High myopic patients with and without foveoschisis: morphological and functional characteristics / Nebbioso, Marcella; Lambiase, A; Gharbiya, M; Bruscolini, A; Alisi, L; Bonfiglio, V.. - In: DOCUMENTA OPHTHALMOLOGICA. - ISSN 0012-4486. - 141:3(2020), pp. 227-236. [10.1007/s10633-020-09767-y]
File allegati a questo prodotto
File Dimensione Formato  
Nebbioso_High myopic patients_2020.pdf

solo gestori archivio

Note: https://link.springer.com/article/10.1007/s10633-020-09767-y
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 854.43 kB
Formato Adobe PDF
854.43 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1391266
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 1
social impact