OBJECTIVE: Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients. THE AIMS OF OUR STUDY WERE: (A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with 'probable' AD and Mild Cognitive Impairment (MCI) due to AD, and in healthy subjects; (B) evaluating epileptiform EEG activity as a function of different sleep stages within a well-controlled polysomnographic setting. METHODS: We prospectively enrolled 50 'probable' AD patients (73 ± 7.0 years) and 50 subjects with MCI due to AD (72 ± 6.7 years) without history of seizures, comparing them with 50 controls (69 ± 6.7 years). Patients underwent to a full-night video-PSG. RESULTS: Subclinical epileptiform activity was detected in 6.38% of 'probable' AD patients, 11.63% of MCI due to AD subjects and 4.54% of controls (p = 0.43). The comparisons between the three groups for the frequency of epileptiform activity did not reach statistically significant differences neither for total sleep nor for any sleep period considered. CONCLUSIONS: Our study shows that, when controlling for sleep stages and the influence of psychoactive drugs, AD patients and MCI due to AD subjects do not exhibit a higher frequency of epileptiform discharges during sleep compared to healthy subjects. SIGNIFICANCE: Subclinical epileptiform activity during sleep does not discriminate 'probable' AD from MCI due to AD and healthy controls.

Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment / Brunetti, Valerio; D'Atri, Aurora; Della Marca, Giacomo; Vollono, Catello; Marra, Camillo; Vita, Maria Gabriella; Scarpelli, Serena; De Gennaro, Luigi; Rossini, Paolo Maria. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1872-8952. - 131:5(2020), pp. 1011-1018. [10.1016/j.clinph.2020.02.015]

Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment

D'Atri, Aurora;Scarpelli, Serena;De Gennaro, Luigi;
2020

Abstract

OBJECTIVE: Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients. THE AIMS OF OUR STUDY WERE: (A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with 'probable' AD and Mild Cognitive Impairment (MCI) due to AD, and in healthy subjects; (B) evaluating epileptiform EEG activity as a function of different sleep stages within a well-controlled polysomnographic setting. METHODS: We prospectively enrolled 50 'probable' AD patients (73 ± 7.0 years) and 50 subjects with MCI due to AD (72 ± 6.7 years) without history of seizures, comparing them with 50 controls (69 ± 6.7 years). Patients underwent to a full-night video-PSG. RESULTS: Subclinical epileptiform activity was detected in 6.38% of 'probable' AD patients, 11.63% of MCI due to AD subjects and 4.54% of controls (p = 0.43). The comparisons between the three groups for the frequency of epileptiform activity did not reach statistically significant differences neither for total sleep nor for any sleep period considered. CONCLUSIONS: Our study shows that, when controlling for sleep stages and the influence of psychoactive drugs, AD patients and MCI due to AD subjects do not exhibit a higher frequency of epileptiform discharges during sleep compared to healthy subjects. SIGNIFICANCE: Subclinical epileptiform activity during sleep does not discriminate 'probable' AD from MCI due to AD and healthy controls.
2020
Alzheimer’s disease; epilepsy; mild cognitive impairment; sleep; subclinical epileptiform activity
01 Pubblicazione su rivista::01a Articolo in rivista
Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment / Brunetti, Valerio; D'Atri, Aurora; Della Marca, Giacomo; Vollono, Catello; Marra, Camillo; Vita, Maria Gabriella; Scarpelli, Serena; De Gennaro, Luigi; Rossini, Paolo Maria. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1872-8952. - 131:5(2020), pp. 1011-1018. [10.1016/j.clinph.2020.02.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1391261
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