Recent data support the theory of the involvement of IL-17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL-17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL-17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.

IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases. State of art / Bernardini, N.; Skroza, N.; Tolino, E.; Mambrin, A.; Anzalone, A.; Balduzzi, V.; Colapietra, D.; Marchesiello, A.; Michelini, S.; Proietti, I.; Potenza, C.. - In: INTERNATIONAL JOURNAL OF DERMATOLOGY. - ISSN 0011-9059. - 59:4(2020), pp. 406-411. [10.1111/ijd.14695]

IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases. State of art

Bernardini N.
;
Skroza N.;Tolino E.;Mambrin A.;Anzalone A.;Balduzzi V.;Colapietra D.;Marchesiello A.;Michelini S.;Proietti I.;Potenza C.
2020

Abstract

Recent data support the theory of the involvement of IL-17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL-17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL-17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.
IL-17; inflammatory desease; autoimmune desease
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases. State of art / Bernardini, N.; Skroza, N.; Tolino, E.; Mambrin, A.; Anzalone, A.; Balduzzi, V.; Colapietra, D.; Marchesiello, A.; Michelini, S.; Proietti, I.; Potenza, C.. - In: INTERNATIONAL JOURNAL OF DERMATOLOGY. - ISSN 0011-9059. - 59:4(2020), pp. 406-411. [10.1111/ijd.14695]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1389611
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