Thymic carcinoma (TC), the rarer among Thymic Epithelial Tumors (TET), occur with an incidence rate of 0.2-0.5/million/yr. Difficulties in the evaluation of molecular aspects derive from the extreme rarity of these tumors. The Squamous cell carcinoma (SQCC) is the most frequently analyzed, however the other rarer histotypes could differ both in molecular pathogenesis and in clinical behaviour. The Cancer Genome Atlas Thymoma study (TCGA-THYM) in a series of ten TC cases including four SQCC, four undifferentiated carcinoma and both one large cell neuroendocrine carcinoma as well as one TC, NOS, identified a few genes rarely mutated, including KIT, HRAS, NRAS and TP53, reflecting the low mutational burden of these tumors (1).
Novel biomarkers for thymic carcinoma / Casini, B.; Gallo, E.; Melis, E.; Cecere, F.; Laquintana, V.; Cerasoli, V.; Facciolo, F.; Pescarmona, E.; Fazi, F.; Marino, M.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 14:10S(2019), pp. S169-S170. (Intervento presentato al convegno IASLC 2019 World Conference on Lung Cancer tenutosi a Barcelona, Spain) [10.1016/j.jtho.2019.08.338].
Novel biomarkers for thymic carcinoma
Pescarmona, E.;Fazi, F.;
2019
Abstract
Thymic carcinoma (TC), the rarer among Thymic Epithelial Tumors (TET), occur with an incidence rate of 0.2-0.5/million/yr. Difficulties in the evaluation of molecular aspects derive from the extreme rarity of these tumors. The Squamous cell carcinoma (SQCC) is the most frequently analyzed, however the other rarer histotypes could differ both in molecular pathogenesis and in clinical behaviour. The Cancer Genome Atlas Thymoma study (TCGA-THYM) in a series of ten TC cases including four SQCC, four undifferentiated carcinoma and both one large cell neuroendocrine carcinoma as well as one TC, NOS, identified a few genes rarely mutated, including KIT, HRAS, NRAS and TP53, reflecting the low mutational burden of these tumors (1).| File | Dimensione | Formato | |
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