In the present opinion article we highlight evidence from different laboratories to drive the attention of the scientific community on the role played by endo-lysosomal Two-Pore Channels (TPCs) in viral infection. In particular, cross linking of our recent data and existing literature, we focus on evidence indicating that virus intracellular pathway could be targeted by a novel occurring TPCs inhibitor, the flavonoid Naringenin. A conceptual framework is presented for considering such a strategy as a promising approach to limit the infection mediated by the novel coronavirus SARS-CoV-2. Our hypothesis offers a perspective on a novel molecular target, TPCs, which could be exploited for a pharmacological blockade of SARS-CoV-2 infectivity.

Could the inhibition of endo-lysosomal two-pore channels (TPCs) by the natural flavonoid naringenin represent an option to fight SARS-COV-2 infection? / Filippini, Antonio; Carpaneto, Armando; D'Amore, Antonella; Palombi, Fioretta. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - (2020). [10.3389/fmicb.2020.00970]

Could the inhibition of endo-lysosomal two-pore channels (TPCs) by the natural flavonoid naringenin represent an option to fight SARS-COV-2 infection?

Antonio Filippini
;
Antonella D'amore
Investigation
;
Fioretta Palombi
2020

Abstract

In the present opinion article we highlight evidence from different laboratories to drive the attention of the scientific community on the role played by endo-lysosomal Two-Pore Channels (TPCs) in viral infection. In particular, cross linking of our recent data and existing literature, we focus on evidence indicating that virus intracellular pathway could be targeted by a novel occurring TPCs inhibitor, the flavonoid Naringenin. A conceptual framework is presented for considering such a strategy as a promising approach to limit the infection mediated by the novel coronavirus SARS-CoV-2. Our hypothesis offers a perspective on a novel molecular target, TPCs, which could be exploited for a pharmacological blockade of SARS-CoV-2 infectivity.
2020
naringenin; SARS - CoV; antiviral treatment; endo-lysosomal dysfunction; therapeutic targets
01 Pubblicazione su rivista::01a Articolo in rivista
Could the inhibition of endo-lysosomal two-pore channels (TPCs) by the natural flavonoid naringenin represent an option to fight SARS-COV-2 infection? / Filippini, Antonio; Carpaneto, Armando; D'Amore, Antonella; Palombi, Fioretta. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - (2020). [10.3389/fmicb.2020.00970]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1388305
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