Antibiotic resistance refers to when microorganisms survive and grow in the presence of specific antibiotics, a phenomenon mainly related to the indiscriminate widespread use and abuse of antibiotics. In this framework, thanks to the design and fabrication of original functional nanomaterials, nanotechnology offers a powerful weapon against several diseases such as cancer and pathogenic illness. Smart nanomaterials, such as metallic nanoparticles and semiconductor nanocrystals, enable the realization of novel drug-free medical therapies for fighting against antibiotic-resistant bacteria. In the light of the latest developments, we highlight the outstanding capabilities of several nanotechnology-inspired approaches to kill antibiotic-resistant bacteria. Chemically functionalized silver and titanium dioxide nanoparticles have been employed for their intrinsic toxicity, which enables them to exhibit an antimicrobial activity while, in a different approach, photo-thermal properties of metallic nanoparticles have been theoretically studied and experimentally tested against several temperature sensitive (mesophilic) bacteria. We also show that it is possible to combine a highly localized targeting with a plasmonic-based heating therapy by properly functionalizing nanoparticle surfaces with covalently linked antibodies. As a perspective, the utilization of properly engineered and chemically functionalized nanomaterials opens a new roads for realizing antibiotic free treatments against pathogens and related diseases.

Antimicrobial effects of chemically functionalized and/or photo-heated nanoparticles / Pezzi, L.; Pane, A.; Annesi, F.; Losso, M. A.; Guglielmelli, A.; Umeton, C.; De Sio, L.. - In: MATERIALS. - ISSN 1996-1944. - 12:7(2019). [10.3390/ma12071078]

Antimicrobial effects of chemically functionalized and/or photo-heated nanoparticles

De Sio L.
Writing – Review & Editing
2019

Abstract

Antibiotic resistance refers to when microorganisms survive and grow in the presence of specific antibiotics, a phenomenon mainly related to the indiscriminate widespread use and abuse of antibiotics. In this framework, thanks to the design and fabrication of original functional nanomaterials, nanotechnology offers a powerful weapon against several diseases such as cancer and pathogenic illness. Smart nanomaterials, such as metallic nanoparticles and semiconductor nanocrystals, enable the realization of novel drug-free medical therapies for fighting against antibiotic-resistant bacteria. In the light of the latest developments, we highlight the outstanding capabilities of several nanotechnology-inspired approaches to kill antibiotic-resistant bacteria. Chemically functionalized silver and titanium dioxide nanoparticles have been employed for their intrinsic toxicity, which enables them to exhibit an antimicrobial activity while, in a different approach, photo-thermal properties of metallic nanoparticles have been theoretically studied and experimentally tested against several temperature sensitive (mesophilic) bacteria. We also show that it is possible to combine a highly localized targeting with a plasmonic-based heating therapy by properly functionalizing nanoparticle surfaces with covalently linked antibodies. As a perspective, the utilization of properly engineered and chemically functionalized nanomaterials opens a new roads for realizing antibiotic free treatments against pathogens and related diseases.
2019
antibacterial agents; antibiotic resistance; gold nanoparticles; plasmonic resonance; thermal inactivation
01 Pubblicazione su rivista::01a Articolo in rivista
Antimicrobial effects of chemically functionalized and/or photo-heated nanoparticles / Pezzi, L.; Pane, A.; Annesi, F.; Losso, M. A.; Guglielmelli, A.; Umeton, C.; De Sio, L.. - In: MATERIALS. - ISSN 1996-1944. - 12:7(2019). [10.3390/ma12071078]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1388303
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