Introduction: A range of combination chemotherapy regimens are currently used in clinical practice. However, international antiemetic guidelines often only categorize the emetogenic potential of single agents rather than the emetogenicity of combination chemotherapy regimens. To manage the nausea and vomiting induced by antineoplastic combinations, guidelines suggest antiemetics that are appropriate for the component drug with the highest emetogenic potential. Furthermore, antiemetic guidelines generally do not consider the influence of other factors, including individual patient characteristics, on the emetic effects of cancer treatments. Similarly, the emetogenic potential of radiotherapy is stratified only according to the site of radiation, while other factors contributing to emetic risk are overlooked. Areas covered: An Expert Panel was convened to examine unresolved issues and summarize the current clinical research on managing nausea and vomiting associated with combination chemotherapy and radiotherapy. Expert opinion: The panel identified the incidence of nausea and vomiting induced by multi-drug combination therapies currently used to treat cancer at different anatomic sites and by radiotherapy in the presence of other risk factors. Based on these data and the clinical experience of panel members, several suggestions are made for a practical approach to prevent or manage nausea and vomiting due to chemotherapy regimens and radiation therapy.

A multidisciplinary expert opinion on CINV and RINV, unmet needs and practical real-life approaches / Bossi, P.; Airoldi, M.; Aloe Spiriti, M. A.; Antonuzzo, A.; Bonciarelli, G.; Campagna, A.; Cassano, A.; Murialdo, R.; Musio, D.; Silvano, G.. - In: EXPERT OPINION ON DRUG SAFETY. - ISSN 1474-0338. - 19:2(2020), pp. 187-204. [10.1080/14740338.2020.1724955]

A multidisciplinary expert opinion on CINV and RINV, unmet needs and practical real-life approaches

Aloe Spiriti M. A.;
2020

Abstract

Introduction: A range of combination chemotherapy regimens are currently used in clinical practice. However, international antiemetic guidelines often only categorize the emetogenic potential of single agents rather than the emetogenicity of combination chemotherapy regimens. To manage the nausea and vomiting induced by antineoplastic combinations, guidelines suggest antiemetics that are appropriate for the component drug with the highest emetogenic potential. Furthermore, antiemetic guidelines generally do not consider the influence of other factors, including individual patient characteristics, on the emetic effects of cancer treatments. Similarly, the emetogenic potential of radiotherapy is stratified only according to the site of radiation, while other factors contributing to emetic risk are overlooked. Areas covered: An Expert Panel was convened to examine unresolved issues and summarize the current clinical research on managing nausea and vomiting associated with combination chemotherapy and radiotherapy. Expert opinion: The panel identified the incidence of nausea and vomiting induced by multi-drug combination therapies currently used to treat cancer at different anatomic sites and by radiotherapy in the presence of other risk factors. Based on these data and the clinical experience of panel members, several suggestions are made for a practical approach to prevent or manage nausea and vomiting due to chemotherapy regimens and radiation therapy.
2020
Antiemetics; chemotherapy; CINV; granisetron; guidelines; nausea; radiotherapy; RINV; vomiting; antineoplastic Combined Chemotherapy Protocols; Humans; Incidence; Nausea; Neoplasms; Practice Guidelines as Topic; Radiotherapy; Risk Factors; Vomiting
01 Pubblicazione su rivista::01a Articolo in rivista
A multidisciplinary expert opinion on CINV and RINV, unmet needs and practical real-life approaches / Bossi, P.; Airoldi, M.; Aloe Spiriti, M. A.; Antonuzzo, A.; Bonciarelli, G.; Campagna, A.; Cassano, A.; Murialdo, R.; Musio, D.; Silvano, G.. - In: EXPERT OPINION ON DRUG SAFETY. - ISSN 1474-0338. - 19:2(2020), pp. 187-204. [10.1080/14740338.2020.1724955]
File allegati a questo prodotto
File Dimensione Formato  
Bossi_A-multidisciplinary_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.64 MB
Formato Adobe PDF
1.64 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1386727
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact