Administration of murine recombinant IL-3 to sublethally irradiated mice induced in the thymus recovery of the cell count and mitotic responsiveness to ConA, as well as a decrease in CD4-CD8- cells concomitant with an increase in CD4+CD8- cells. The cell count and mitotic responsiveness to ConA and LPS, as well as antibody response and helper activity, were also recovered in the spleen by IL-3 treatment. These findings show that IL-3 induces differentiation and growth of thymocytes and full recovery of T and B cell functions in sublethally irradiated mice.
IL-3 induces differentiation and growth of thymocytes and splenic T and B lymphocytes in irradiated mice / Frasca, D; Zingoni, Alessandra; Leter, G; Spano, M. AND DORIA G.. - In: JOURNAL OF IMMUNOLOGICAL RESEARCH. - ISSN 1120-3765. - STAMPA. - 4:(1992), pp. 61-66.
IL-3 induces differentiation and growth of thymocytes and splenic T and B lymphocytes in irradiated mice
ZINGONI, Alessandra;
1992
Abstract
Administration of murine recombinant IL-3 to sublethally irradiated mice induced in the thymus recovery of the cell count and mitotic responsiveness to ConA, as well as a decrease in CD4-CD8- cells concomitant with an increase in CD4+CD8- cells. The cell count and mitotic responsiveness to ConA and LPS, as well as antibody response and helper activity, were also recovered in the spleen by IL-3 treatment. These findings show that IL-3 induces differentiation and growth of thymocytes and full recovery of T and B cell functions in sublethally irradiated mice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
