Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-β peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO ≤ 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors. In PD, AO directly correlated to either CSF lactate and tau proteins or the nonmotor symptoms scale score. Specifically, a younger AO was associated with lower levels of biomarkers and minor burden of nonmotor symptoms. Our findings indicate that clinical-biochemical features of idiopathic PD may vary depending on the AO, accounting for different profiles in YOPD and LOPD whose recognition is fundamental for further pathophysiological implications and clinical applications.

Young-onset and late-onset Parkinson's disease exhibit a different profile of fluid biomarkers and clinical features / Schirinzi, T.; Di Lazzaro, G.; Sancesario, G. M.; Summa, S.; Petrucci, S.; Colona, V. L.; Bernardini, S.; Pierantozzi, M.; Stefani, A.; Mercuri, N. B.; Pisani, A.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 90:(2020), pp. 119-124. [10.1016/j.neurobiolaging.2020.02.012]

Young-onset and late-onset Parkinson's disease exhibit a different profile of fluid biomarkers and clinical features

Schirinzi T.
;
Di Lazzaro G.;Summa S.;Petrucci S.;
2020

Abstract

Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-β peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO ≤ 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors. In PD, AO directly correlated to either CSF lactate and tau proteins or the nonmotor symptoms scale score. Specifically, a younger AO was associated with lower levels of biomarkers and minor burden of nonmotor symptoms. Our findings indicate that clinical-biochemical features of idiopathic PD may vary depending on the AO, accounting for different profiles in YOPD and LOPD whose recognition is fundamental for further pathophysiological implications and clinical applications.
2020
aging; early-onset parkinson's disease; fluid biomarkers; late-onset parkinson's disease; young-onset parkinson's disease
01 Pubblicazione su rivista::01a Articolo in rivista
Young-onset and late-onset Parkinson's disease exhibit a different profile of fluid biomarkers and clinical features / Schirinzi, T.; Di Lazzaro, G.; Sancesario, G. M.; Summa, S.; Petrucci, S.; Colona, V. L.; Bernardini, S.; Pierantozzi, M.; Stefani, A.; Mercuri, N. B.; Pisani, A.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 90:(2020), pp. 119-124. [10.1016/j.neurobiolaging.2020.02.012]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1383067
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