Abnormal adrenal function can interfere with linear growth, potentially causing either acceleration or impairment of growth in paediatric patients. These abnormalities can be caused by direct effects of adrenal hormones, particularly glucocorticoids and sex steroids, or be mediated by indirect mechanisms such as the disturbance of the growth hormone-insulin-like growth factor-1 axis and aromatization of androgens to oestrogens. The early diagnosis and optimal treatment of adrenal disorders can prevent or minimize growth disturbance and facilitate improved height gain. Mechanisms of growth disturbance in the following abnormal states will be discussed; hypercortisolaemia, hyperandrogenaemia and obesity. Prevalence and features of growth disturbance will be discussed in ACTH-dependent and ACTH-independent Cushing's syndrome, adrenocortical tumours, premature adrenarche, congenital adrenal hyperplasia and adrenal insufficiency disorders. Recommendations for management have been included.

Abnormal linear growth in paediatric adrenal diseases: Pathogenesis, prevalence and management / Minnetti, M.; Caiulo, S.; Ferrigno, R.; Baldini-Ferroli, B.; Bottaro, G.; Gianfrilli, D.; Sbardella, E.; De Martino, M. C.; Savage, M. O.. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - 92:2(2020), pp. 98-108. [10.1111/cen.14131]

Abnormal linear growth in paediatric adrenal diseases: Pathogenesis, prevalence and management

Minnetti M.;Gianfrilli D.;Sbardella E.;
2020

Abstract

Abnormal adrenal function can interfere with linear growth, potentially causing either acceleration or impairment of growth in paediatric patients. These abnormalities can be caused by direct effects of adrenal hormones, particularly glucocorticoids and sex steroids, or be mediated by indirect mechanisms such as the disturbance of the growth hormone-insulin-like growth factor-1 axis and aromatization of androgens to oestrogens. The early diagnosis and optimal treatment of adrenal disorders can prevent or minimize growth disturbance and facilitate improved height gain. Mechanisms of growth disturbance in the following abnormal states will be discussed; hypercortisolaemia, hyperandrogenaemia and obesity. Prevalence and features of growth disturbance will be discussed in ACTH-dependent and ACTH-independent Cushing's syndrome, adrenocortical tumours, premature adrenarche, congenital adrenal hyperplasia and adrenal insufficiency disorders. Recommendations for management have been included.
2020
adrenal disorders; adult height; growth plate; height; hyperandrogenism; hypercortisolaemia; paediatric
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Abnormal linear growth in paediatric adrenal diseases: Pathogenesis, prevalence and management / Minnetti, M.; Caiulo, S.; Ferrigno, R.; Baldini-Ferroli, B.; Bottaro, G.; Gianfrilli, D.; Sbardella, E.; De Martino, M. C.; Savage, M. O.. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - 92:2(2020), pp. 98-108. [10.1111/cen.14131]
File allegati a questo prodotto
File Dimensione Formato  
Minnetti_Abnormal-linear-growth_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 390.62 kB
Formato Adobe PDF
390.62 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1380988
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 18
social impact