Purpose: The objective of this study was to evaluate the impact of hormone replacement therapy (HRT) on the prognosis in endometrial cancer (EC) survivors. Methods: The research was conducted using the following electronic databases: MEDLINE (PubMed), Web of Science, ClinicalTrial.gov, and Cochrane Library. We performed a review of studies published from January 1986 to January 2019. We selected studies that included EC patients submitted to surgery with curative intent and postoperative use of HRT. Result: Seven of 1,332 abstracts considered were eligible: 4 retrospective series, 1 prospective study, 1 randomized controlled trial, and 1 population study. Globally in the observed studies there was not a significant increase in the recurrence rate, measured by the relative risk, in the EC survivors using HRT compared with the controls in tumour stages I and II. The bias was that HRT was prescribed only to low-risk patients, who were young and had a low stage of disease. Conclusion: This systematic review shows that HRT use had no negative effect on prognosis in EC survivors in tumour stages I and II.

Does Hormone Replacement Therapy Impact the Prognosis in Endometrial Cancer Survivors? A Systematic Review / Di Donato, Violante; Palaia, Innocenza; D'Aniello, Debora; Musacchio, Lucia; Santangelo, Giusi; Di mauro, Federica; Di Pinto, Anna; Musella, Angela; Fischetti, Margherita; Tomao, Federica; Perniola, Giorgia; Benedetti Panici, Pierluigi. - In: ONCOLOGY. - ISSN 0030-2414. - (2020), pp. 1-7. [10.1159/000505427]

Does Hormone Replacement Therapy Impact the Prognosis in Endometrial Cancer Survivors? A Systematic Review

Di Donato, Violante;Palaia, Innocenza;D'Aniello, Debora
;
Musacchio, Lucia;Santangelo, Giusi;Di Pinto, Anna;Musella, Angela;Fischetti, Margherita;Tomao, Federica;Perniola, Giorgia;Benedetti Panici, Pierluigi
2020

Abstract

Purpose: The objective of this study was to evaluate the impact of hormone replacement therapy (HRT) on the prognosis in endometrial cancer (EC) survivors. Methods: The research was conducted using the following electronic databases: MEDLINE (PubMed), Web of Science, ClinicalTrial.gov, and Cochrane Library. We performed a review of studies published from January 1986 to January 2019. We selected studies that included EC patients submitted to surgery with curative intent and postoperative use of HRT. Result: Seven of 1,332 abstracts considered were eligible: 4 retrospective series, 1 prospective study, 1 randomized controlled trial, and 1 population study. Globally in the observed studies there was not a significant increase in the recurrence rate, measured by the relative risk, in the EC survivors using HRT compared with the controls in tumour stages I and II. The bias was that HRT was prescribed only to low-risk patients, who were young and had a low stage of disease. Conclusion: This systematic review shows that HRT use had no negative effect on prognosis in EC survivors in tumour stages I and II.
2020
endometrial cancer; hormone replacement therapy; oestrogen therapy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Does Hormone Replacement Therapy Impact the Prognosis in Endometrial Cancer Survivors? A Systematic Review / Di Donato, Violante; Palaia, Innocenza; D'Aniello, Debora; Musacchio, Lucia; Santangelo, Giusi; Di mauro, Federica; Di Pinto, Anna; Musella, Angela; Fischetti, Margherita; Tomao, Federica; Perniola, Giorgia; Benedetti Panici, Pierluigi. - In: ONCOLOGY. - ISSN 0030-2414. - (2020), pp. 1-7. [10.1159/000505427]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1378647
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