Introduction: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage and fibrosis of the skin and internal organs. The major complications are lung fibrosis, pulmonary artery hypertension, scleroderma renal crisis, and cardiac involvement. Objective: The aim of this study was to assess renal and cardiac involvement in asymptomatic SSc patients using renal Doppler ultrasound (RDU) and cardiac magnetic resonance (CMR). Materials and Methods: We enrolled 26 consecutive SSc patients (21 female) according to 2013 ACR/EULAR criteria. Biochemical analysis, clinical evaluation, RDU with intrarenal hemodynamic parameters (renal resistive index [RRI], pulsatility index [PI], systolic/diastolic [S/D] ratio), and CMR with late gadolinium enhancement (LGE) were investigated at the time of enrollment. Results: The median PI value was significantly (p = 0.007) higher in SSc patients with LGE than in SSc patients without LGE (1.37 [1.28-1.58] vs. 1.12 [1.06-1.26]). The median RRI value was significantly (p = 0.002) higher in SSc patients with LGE than in SSc patients without LGE (0.68 [0.65-0.73] vs. 0.64 [0.63-0.65]). The median S/D ratio was significantly (p = 0.02) higher in SSc patients with LGE than in SSc patients without LGE (3.12 [2.83-3.76] vs. 2.78 [2.64-2.84]). Conclusions: Our study, although performed on a small SSc population, showed RRI and LGE as markers of vascular and fibrotic damage. Early detection of cardiorenal involvement in SSc patients without symptoms is important to avoid further complications.

Late gadolinium enhancement in cardiac magnetic resonance imaging is associated with high renal resistive index in patients with systemic sclerosis / Cianci, Rosario; Gigante, Antonietta; GASPERINI ZACCO, MARIA LUDOVICA; Barbano, Biagio; Galea, Nicola; Rosato, Edoardo. - In: KIDNEY & BLOOD PRESSURE RESEARCH. - ISSN 1420-4096. - 45:2(2020), pp. 350-356. [10.1159/000505659]

Late gadolinium enhancement in cardiac magnetic resonance imaging is associated with high renal resistive index in patients with systemic sclerosis

Rosario Cianci;Antonietta Gigante
;
Maria Ludovica Gasperini;Biagio Barbano;Nicola Galea;Edoardo Rosato
2020

Abstract

Introduction: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage and fibrosis of the skin and internal organs. The major complications are lung fibrosis, pulmonary artery hypertension, scleroderma renal crisis, and cardiac involvement. Objective: The aim of this study was to assess renal and cardiac involvement in asymptomatic SSc patients using renal Doppler ultrasound (RDU) and cardiac magnetic resonance (CMR). Materials and Methods: We enrolled 26 consecutive SSc patients (21 female) according to 2013 ACR/EULAR criteria. Biochemical analysis, clinical evaluation, RDU with intrarenal hemodynamic parameters (renal resistive index [RRI], pulsatility index [PI], systolic/diastolic [S/D] ratio), and CMR with late gadolinium enhancement (LGE) were investigated at the time of enrollment. Results: The median PI value was significantly (p = 0.007) higher in SSc patients with LGE than in SSc patients without LGE (1.37 [1.28-1.58] vs. 1.12 [1.06-1.26]). The median RRI value was significantly (p = 0.002) higher in SSc patients with LGE than in SSc patients without LGE (0.68 [0.65-0.73] vs. 0.64 [0.63-0.65]). The median S/D ratio was significantly (p = 0.02) higher in SSc patients with LGE than in SSc patients without LGE (3.12 [2.83-3.76] vs. 2.78 [2.64-2.84]). Conclusions: Our study, although performed on a small SSc population, showed RRI and LGE as markers of vascular and fibrotic damage. Early detection of cardiorenal involvement in SSc patients without symptoms is important to avoid further complications.
2020
cardiac magnetic resonance; late gadolinium enhancement; renal doppler ultrasound; renal resistive index; systemic sclerosis
01 Pubblicazione su rivista::01a Articolo in rivista
Late gadolinium enhancement in cardiac magnetic resonance imaging is associated with high renal resistive index in patients with systemic sclerosis / Cianci, Rosario; Gigante, Antonietta; GASPERINI ZACCO, MARIA LUDOVICA; Barbano, Biagio; Galea, Nicola; Rosato, Edoardo. - In: KIDNEY & BLOOD PRESSURE RESEARCH. - ISSN 1420-4096. - 45:2(2020), pp. 350-356. [10.1159/000505659]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1375446
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