Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions. © 2018 CSI and USTC.

Chemokine and chemotactic signals in dendritic cell migration / Tiberio, Laura; Del Prete, Annalisa; Schioppa, Tiziana; Sozio, Francesca; Bosisio, Daniela; Sozzani, Silvano. - In: CELLULAR & MOLECULAR IMMUNOLOGY. - ISSN 1672-7681. - 15:4(2018). [10.1038/s41423-018-0005-3]

Chemokine and chemotactic signals in dendritic cell migration

SOZIO, Francesca;Sozzani, Silvano
2018

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions. © 2018 CSI and USTC.
2018
dendritic cells; T-lymphocytes; plasmacytoid DCs
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Chemokine and chemotactic signals in dendritic cell migration / Tiberio, Laura; Del Prete, Annalisa; Schioppa, Tiziana; Sozio, Francesca; Bosisio, Daniela; Sozzani, Silvano. - In: CELLULAR & MOLECULAR IMMUNOLOGY. - ISSN 1672-7681. - 15:4(2018). [10.1038/s41423-018-0005-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1371185
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