Lymph node (LN) expansion during inflammation is essential to establish immune responses and relies on the development of blood and lymph vessels. Human dendritic cells (DCs), subdivided into two main subsets, namely conventional DCs (cDCs) and plasmacytoid DCs (pDCs), are professional antigen presenting cells endowed with the capability to produce soluble mediators regulating inflammation and tissue repair. cDCs support angiogenesis in secondary LNs both directly and indirectly through the secretion of vascular endothelial growth factor-A (VEGF)-A and VEGF-C and the production of several other mediators endowed with angiogenic properties. Finally, cDCs can affect neovascular formation via a transdifferentiation process. At variance with cDCs, the angiogenic properties of pDCs still remain poorly explored.

Dendritic cells in inflammatory angiogenesis and lymphangiogenesis / Bosisio, Daniela; Ronca, Roberto; Salvi, Valentina; Presta, Marco; Sozzani, Silvano. - In: CURRENT OPINION IN IMMUNOLOGY. - ISSN 0952-7915. - 53:(2018), pp. 180-186. [10.1016/j.coi.2018.05.011]

Dendritic cells in inflammatory angiogenesis and lymphangiogenesis

Sozzani, Silvano
2018

Abstract

Lymph node (LN) expansion during inflammation is essential to establish immune responses and relies on the development of blood and lymph vessels. Human dendritic cells (DCs), subdivided into two main subsets, namely conventional DCs (cDCs) and plasmacytoid DCs (pDCs), are professional antigen presenting cells endowed with the capability to produce soluble mediators regulating inflammation and tissue repair. cDCs support angiogenesis in secondary LNs both directly and indirectly through the secretion of vascular endothelial growth factor-A (VEGF)-A and VEGF-C and the production of several other mediators endowed with angiogenic properties. Finally, cDCs can affect neovascular formation via a transdifferentiation process. At variance with cDCs, the angiogenic properties of pDCs still remain poorly explored.
2018
immunology and allergy; immunology; dendritic cells
01 Pubblicazione su rivista::01a Articolo in rivista
Dendritic cells in inflammatory angiogenesis and lymphangiogenesis / Bosisio, Daniela; Ronca, Roberto; Salvi, Valentina; Presta, Marco; Sozzani, Silvano. - In: CURRENT OPINION IN IMMUNOLOGY. - ISSN 0952-7915. - 53:(2018), pp. 180-186. [10.1016/j.coi.2018.05.011]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1371166
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