Extracellular vesicles (EVs) have emerged as key regulators of cell-cell communication during inflammatory responses to lung injury induced by diverse pulmonary toxicants including cigarette smoke, air pollutants, hyperoxia, acids, and endotoxin. Many lung cell types, including epithelial cells and endothelial cells, as well as infiltrating macrophages generate EVs. EVs appear to function by transporting cargo to recipient cells that, in most instances, promote their inflammatory activity. Biologically active cargo transported by EVs include miRNAs, cytokines/chemokines, damage-associated molecular patterns (DAMPs), tissue factor (TF)s, and caspases. Findings that EVs are taken up by target cells such as macrophages, and that this leads to increased proinflammatory functioning provide support for their role in the development of pathologies associated with toxicant exposure. Understanding the nature of EVs responding to toxic exposures and their cargo may lead to the development of novel therapeutic approaches to mitigating lung injury.

Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants / Andres, J.; Smith, L. C.; Murray, A.; Jin, Y.; Businaro, R.; Laskin, J. D.; Laskin, D. L.. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - 51:(2020), pp. 12-18. [10.1016/j.cytogfr.2019.12.001]

Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants

Businaro R.;
2020

Abstract

Extracellular vesicles (EVs) have emerged as key regulators of cell-cell communication during inflammatory responses to lung injury induced by diverse pulmonary toxicants including cigarette smoke, air pollutants, hyperoxia, acids, and endotoxin. Many lung cell types, including epithelial cells and endothelial cells, as well as infiltrating macrophages generate EVs. EVs appear to function by transporting cargo to recipient cells that, in most instances, promote their inflammatory activity. Biologically active cargo transported by EVs include miRNAs, cytokines/chemokines, damage-associated molecular patterns (DAMPs), tissue factor (TF)s, and caspases. Findings that EVs are taken up by target cells such as macrophages, and that this leads to increased proinflammatory functioning provide support for their role in the development of pathologies associated with toxicant exposure. Understanding the nature of EVs responding to toxic exposures and their cargo may lead to the development of novel therapeutic approaches to mitigating lung injury.
2020
cigarette smoke; epithelial cells; inflammation; lipopolysaccharide; macrophages; ozone
01 Pubblicazione su rivista::01a Articolo in rivista
Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants / Andres, J.; Smith, L. C.; Murray, A.; Jin, Y.; Businaro, R.; Laskin, J. D.; Laskin, D. L.. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - 51:(2020), pp. 12-18. [10.1016/j.cytogfr.2019.12.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1362792
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