Exercise-induced epigenetic modifications for beneficial health manifestations

In the wake of multiple observations arising from diverse corners of physiological and molecular genetics, the onslaught of epigenetic changes, gene x environment interaction, under current appearances requires rendition for purposes of displaying both performance augmentation, amelioration of structural-functional impairment and the promotion of resilience manifested by the lasting health benefits that arise from regular and consistent physical exercise. The notion that individuals, who maintain an exercise habit that is pursued with regularity, incorporating appropriate combinations of endurance and resistance, will present lower levels of “epigenetic ageing”, experience lesser metabolic disorders and express higher levels of longevity. The relationships and outcomes of the exercise influences upon epigenetic mechanisms are viewed from several angles, including: diet-exercise interactions, cognitive progression, maintenance and sustainability and cholinergic detriment over the very young, young, mature and aged, i.e. the complete lifespan. Although the numerous health advantages granted by regular physical exercise remain unequivocal it appears to be case that a plethora of the molecular and tissue adaptations will confer heritable health implications, hopefully positive, for future generations.