Objective: To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study. Materials and methods: From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB). Results: We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA, p = 0.20; p = 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%]; p = 0.13). Conclusion: We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations. Key Points: • Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%). • Image quality varies between sites and can be improved by feedback given by the core lab. • Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.
Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography / De Rubeis, G.; Napp, A. E.; Schlattmann, P.; Geleijns, J.; Laule, M.; Dreger, H.; Kofoed, K.; Sorgaard, M.; Engstrom, T.; Tilsted, H. H.; Boi, A.; Porcu, M.; Cossa, S.; Rodriguez-Palomares, J. F.; Xavier Valente, F.; Roque, A.; Feuchtner, G.; Plank, F.; Stechovsky, C.; Adla, T.; Schroeder, S.; Zelesny, T.; Gutberlet, M.; Woinke, M.; Karolyi, M.; Karady, J.; Donnelly, P.; Ball, P.; Dodd, J.; Hensey, M.; Mancone, M.; Ceccacci, A.; Berzina, M.; Zvaigzne, L.; Sakalyte, G.; Basevicius, A.; Ilnicka-Suckiel, M.; Kusmierz, D.; Faria, R.; Gama-Ribeiro, V.; Benedek, I.; Benedek, T.; Adjic, F.; Cankovic, M.; Berry, C.; Delles, C.; Thwaite, E.; Davis, G.; Knuuti, J.; Pietila, M.; Kepka, C.; Kruk, M.; Vidakovic, R.; Neskovic, A. N.; Lecumberri, I.; Diez Gonzales, I.; Ruzsics, B.; Fisher, M.; Dewey, M.; Francone, M.. - In: EUROPEAN RADIOLOGY. - ISSN 0938-7994. - 30:4(2020), pp. 1997-2009. [10.1007/s00330-019-06522-z]
Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography
De Rubeis G.Primo
;Mancone M.;Ceccacci A.;Francone M.
Ultimo
2020
Abstract
Objective: To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study. Materials and methods: From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB). Results: We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA, p = 0.20; p = 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%]; p = 0.13). Conclusion: We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations. Key Points: • Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%). • Image quality varies between sites and can be improved by feedback given by the core lab. • Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.| File | Dimensione | Formato | |
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