OBJECTIVES: The role of functional techniques, such as magnetic resonance spectroscopy (H-MRS), as noninvasive tools to increase breast MR imaging reliability has been widely investigated during the last 2 decades. Considering the growing interest in tumor biology and its influence on functional parameters, the aim of this study was to investigate the relationship between H-MRS parameters and breast cancer biomarkers and to evaluate whether the results of H-MRS at 3 T can correlate with established breast cancer prognostic factors in our clinical experience. MATERIALS AND METHODS: One hundred two patients with biopsy-proven breast cancer underwent 3 T breast MR imaging. Single-voxel H-MRS was performed after the T1-weighted sequence, using a PRESS water-suppressed sequence (BREASE). Data were collected from a single rectangular volume of interest that encompassed the lesion. Magnetic resonance images and spectra of 102 Breast Imaging Reporting and Data System 6 lesions were prospectively evaluated by 2 radiologists in consensus. H-MRS results were considered positive if the choline peak signal-to-noise ratio was 2 or higher. H-MRS findings were then compared with morphological features and to histological findings, such as lesion size, nuclear grade, Ki-67, hormone receptor status, and Her2 expression. RESULTS: Elevated levels of total choline were detectable in 68/102 cases (66.67%) and undetectable in 34/102 (33.33%). A statistically significant association between the presence of choline peak and higher tumor grading (P < 0.0001), greater Ki-67 value (P < 0.0001), and larger lesion size (P < 0.0001) was found. No statistically significant associations were observed between choline peak and the luminal subgroups, even if higher levels of choline were more frequent in nonluminal A lesions. CONCLUSIONS: Our study confirms that 3 T breast H-MRS can be a valid additional tool to obtain further information about breast cancer biology and to predict tumor aggressiveness, because the detection of elevated levels of total choline in the spectrum is associated with a biologically aggressive breast cancer phenotype (large dimensions, grade 3, high values of Ki-67). Our results need to be validated in standardized larger-scale studies.

Breast magnetic resonance spectroscopy at 3 T in biopsy-proven breast cancers: does choline peak correlate with prognostic factors? / Galati, F.; Luciani, M. L.; Caramanico, C.; Moffa, G.; Catalano, C.; Pediconi, F.. - In: INVESTIGATIVE RADIOLOGY. - ISSN 0020-9996. - 54:12(2019), pp. 767-773. [10.1097/RLI.0000000000000597]

Breast magnetic resonance spectroscopy at 3 T in biopsy-proven breast cancers: does choline peak correlate with prognostic factors?

Galati F.
Primo
;
Luciani M. L.
Secondo
;
Caramanico C.;Moffa G.;Catalano C.
Penultimo
;
Pediconi F.
Ultimo
2019

Abstract

OBJECTIVES: The role of functional techniques, such as magnetic resonance spectroscopy (H-MRS), as noninvasive tools to increase breast MR imaging reliability has been widely investigated during the last 2 decades. Considering the growing interest in tumor biology and its influence on functional parameters, the aim of this study was to investigate the relationship between H-MRS parameters and breast cancer biomarkers and to evaluate whether the results of H-MRS at 3 T can correlate with established breast cancer prognostic factors in our clinical experience. MATERIALS AND METHODS: One hundred two patients with biopsy-proven breast cancer underwent 3 T breast MR imaging. Single-voxel H-MRS was performed after the T1-weighted sequence, using a PRESS water-suppressed sequence (BREASE). Data were collected from a single rectangular volume of interest that encompassed the lesion. Magnetic resonance images and spectra of 102 Breast Imaging Reporting and Data System 6 lesions were prospectively evaluated by 2 radiologists in consensus. H-MRS results were considered positive if the choline peak signal-to-noise ratio was 2 or higher. H-MRS findings were then compared with morphological features and to histological findings, such as lesion size, nuclear grade, Ki-67, hormone receptor status, and Her2 expression. RESULTS: Elevated levels of total choline were detectable in 68/102 cases (66.67%) and undetectable in 34/102 (33.33%). A statistically significant association between the presence of choline peak and higher tumor grading (P < 0.0001), greater Ki-67 value (P < 0.0001), and larger lesion size (P < 0.0001) was found. No statistically significant associations were observed between choline peak and the luminal subgroups, even if higher levels of choline were more frequent in nonluminal A lesions. CONCLUSIONS: Our study confirms that 3 T breast H-MRS can be a valid additional tool to obtain further information about breast cancer biology and to predict tumor aggressiveness, because the detection of elevated levels of total choline in the spectrum is associated with a biologically aggressive breast cancer phenotype (large dimensions, grade 3, high values of Ki-67). Our results need to be validated in standardized larger-scale studies.
magnetic resonance; spectroscopy; 3T; breast cancers; H-MRS parameters
01 Pubblicazione su rivista::01a Articolo in rivista
Breast magnetic resonance spectroscopy at 3 T in biopsy-proven breast cancers: does choline peak correlate with prognostic factors? / Galati, F.; Luciani, M. L.; Caramanico, C.; Moffa, G.; Catalano, C.; Pediconi, F.. - In: INVESTIGATIVE RADIOLOGY. - ISSN 0020-9996. - 54:12(2019), pp. 767-773. [10.1097/RLI.0000000000000597]
File allegati a questo prodotto
File Dimensione Formato  
Galati_Breast-magnetic-resonance_2019.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 311.81 kB
Formato Adobe PDF
311.81 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1359794
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 11
social impact