Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a very rare CD30-positive ALK-negative T-cell non-Hodgkin lymphoma included as a provisional entity in the 2017 WHO classification of lymphoid neoplasms. BIA-ALCL arises as proliferating cells over the surface of the implant. It is generally an indolent disease if confined within the fibrous capsule. In contrast, mass and/or infiltration beyond the capsule is much more aggressive. This report describes a case of infiltrative BIA-ALCL with massive pleural effusion containing hallmark BIA-ALCL cells showing the characteristic morphologic appearance of high-grade anaplastic lymphoma, CD30-positive but ALK-negative with variable staining for T-cell antigens. Detailed cytological features of BIA-ALCL in pleural fluid are described along with the results of a literature search performed for BIA-ALCL cases with pleural effusion. This report expands the spectrum of BIA-ALCL pathology to include chest wall involvement and pleural effusion.

Cytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion / D'Alessandris, N.; Lucatelli, P.; Tripodi, Domenico; Amabile, M. I.; Ascoli, V.. - In: DIAGNOSTIC CYTOPATHOLOGY. - ISSN 8755-1039. - 47:11(2019), pp. 1213-1217. [10.1002/dc.24287]

Cytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion

D'Alessandris N.
Primo
;
Lucatelli P.
Secondo
;
TRIPODI, DOMENICO;Amabile M. I.
Penultimo
;
Ascoli V.
Ultimo
2019

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a very rare CD30-positive ALK-negative T-cell non-Hodgkin lymphoma included as a provisional entity in the 2017 WHO classification of lymphoid neoplasms. BIA-ALCL arises as proliferating cells over the surface of the implant. It is generally an indolent disease if confined within the fibrous capsule. In contrast, mass and/or infiltration beyond the capsule is much more aggressive. This report describes a case of infiltrative BIA-ALCL with massive pleural effusion containing hallmark BIA-ALCL cells showing the characteristic morphologic appearance of high-grade anaplastic lymphoma, CD30-positive but ALK-negative with variable staining for T-cell antigens. Detailed cytological features of BIA-ALCL in pleural fluid are described along with the results of a literature search performed for BIA-ALCL cases with pleural effusion. This report expands the spectrum of BIA-ALCL pathology to include chest wall involvement and pleural effusion.
2019
ALK-negative anaplastic large cell lymphoma; breast implant; cytological diagnosis; pleural effusion
01 Pubblicazione su rivista::01a Articolo in rivista
Cytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion / D'Alessandris, N.; Lucatelli, P.; Tripodi, Domenico; Amabile, M. I.; Ascoli, V.. - In: DIAGNOSTIC CYTOPATHOLOGY. - ISSN 8755-1039. - 47:11(2019), pp. 1213-1217. [10.1002/dc.24287]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1359139
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