Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemic stroke. Importantly, since epigenetic modifications are reversible processes they could assist with the development of new therapeutic approaches for the treatment of human diseases. In the present review article, we aim to collect the most recent evidence concerning the impact of epigenetic modifications on the pathogenesis of ischemic stroke in both animal models and humans.

Pathogenesis of ischemic stroke: role of epigenetic mechanisms / Stanzione, Rosita; Cotugno, Maria; Bianchi, Franca; Marchitti, Simona; Forte, Maurizio; Volpe, Massimo; Rubattu, Speranza. - In: GENES. - ISSN 2073-4425. - 11:1(2020), pp. 1-13. [10.3390/genes11010089]

Pathogenesis of ischemic stroke: role of epigenetic mechanisms

Stanzione, Rosita
Primo
Conceptualization
;
Cotugno, Maria
Secondo
Methodology
;
Marchitti, Simona
Methodology
;
Volpe, Massimo
Penultimo
Supervision
;
Rubattu, Speranza
Ultimo
Supervision
2020

Abstract

Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemic stroke. Importantly, since epigenetic modifications are reversible processes they could assist with the development of new therapeutic approaches for the treatment of human diseases. In the present review article, we aim to collect the most recent evidence concerning the impact of epigenetic modifications on the pathogenesis of ischemic stroke in both animal models and humans.
2020
DNA methylation; epigenetic; histone modification; ischemic stroke; lncRNA; miRNA
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Pathogenesis of ischemic stroke: role of epigenetic mechanisms / Stanzione, Rosita; Cotugno, Maria; Bianchi, Franca; Marchitti, Simona; Forte, Maurizio; Volpe, Massimo; Rubattu, Speranza. - In: GENES. - ISSN 2073-4425. - 11:1(2020), pp. 1-13. [10.3390/genes11010089]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1353938
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