Background Motor surround inhibition (mSI) is a phenomenon supportive for executing selective finger movements, wherein synergist muscles are selectively facilitated while surround muscles are inhibited. Previous studies of conditioning inputs to several intracortical and cortico-cortical inhibitory networks did not show an influence on mSI. The inhibitory posterior parietal-motor network, which is crucial for executing fine movements, however, has not been studied. Objective/hypothesis To investigate the role of inhibitory posterior parietal-motor network in mSI. We hypothesized that conditioning this inhibitory network would enhance mSI. Methods 11 healthy adults completed study. mSI was elicited by applying a TMS pulse over the motor cortex coupled with or without a conditioning input to an inhibitory spot in the posterior parietal cortex at 2 or 4 ms interval. Results Conditioning input to the posterior parietal cortex increased mSI by ∼20% Conclusion The inhibitory posterior parietal-motor network appears to contribute to the genesis of mSI.
Parietal conditioning enhances motor surround inhibition / Thirugnanasambandam, Nivethida; Leodori, Giorgio; Popa, Traian; Kassavetis, Panagiotis; Mandel, Alexandra; Shaft, Alexander; Kee, Jaron; Kashyap, Sarung; Khodorov, Gregg; Hallett, Mark. - In: BRAIN STIMULATION. - ISSN 1935-861X. - (2019). [10.1016/j.brs.2019.12.011]
Parietal conditioning enhances motor surround inhibition
Leodori, Giorgio;
2019
Abstract
Background Motor surround inhibition (mSI) is a phenomenon supportive for executing selective finger movements, wherein synergist muscles are selectively facilitated while surround muscles are inhibited. Previous studies of conditioning inputs to several intracortical and cortico-cortical inhibitory networks did not show an influence on mSI. The inhibitory posterior parietal-motor network, which is crucial for executing fine movements, however, has not been studied. Objective/hypothesis To investigate the role of inhibitory posterior parietal-motor network in mSI. We hypothesized that conditioning this inhibitory network would enhance mSI. Methods 11 healthy adults completed study. mSI was elicited by applying a TMS pulse over the motor cortex coupled with or without a conditioning input to an inhibitory spot in the posterior parietal cortex at 2 or 4 ms interval. Results Conditioning input to the posterior parietal cortex increased mSI by ∼20% Conclusion The inhibitory posterior parietal-motor network appears to contribute to the genesis of mSI.File | Dimensione | Formato | |
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