Aims: To identify early clinical factors predictive of later morbidity in major depressive disorder (MDD). Methods: We analysed factors associated with long-term depressive morbidity (%-time ill) between a first-lifetime major depressive episode and last follow-up of 116 adults diagnosed with DSM-IV major depressive disorder. Bivariate comparisons were followed by multivariable linear regression modelling. Results: Three factors were independently associated with an average of 25%-time-depressed over 17 years at risk: (a) agitated-mixed, or psychotic features in initial major depressive episodes, (b) anxiety syndromes prior to a first-lifetime major depressive episode, and (c) anxiety symptoms in childhood. Conclusion: Early anxiety symptoms and syndromes and agitated-mixed or psychotic initial depressive episodes predicted more long-term depressive morbidity in MDD.

Early clinical predictors of long-term morbidity in major depressive disorder / Serra, G.; Koukopoulos, A.; De Chiara, L.; Koukopoulos, A. E.; Sani, G.; Tondo, L.; Girardi, P.; Reginaldi, D.; Baldessarini, R. J.. - In: EARLY INTERVENTION IN PSYCHIATRY. - ISSN 1751-7885. - 13:4(2019), pp. 999-1002. [10.1111/eip.12768]

Early clinical predictors of long-term morbidity in major depressive disorder

Serra G.;De Chiara L.;Koukopoulos A. E.;Sani G.;Girardi P.;
2019

Abstract

Aims: To identify early clinical factors predictive of later morbidity in major depressive disorder (MDD). Methods: We analysed factors associated with long-term depressive morbidity (%-time ill) between a first-lifetime major depressive episode and last follow-up of 116 adults diagnosed with DSM-IV major depressive disorder. Bivariate comparisons were followed by multivariable linear regression modelling. Results: Three factors were independently associated with an average of 25%-time-depressed over 17 years at risk: (a) agitated-mixed, or psychotic features in initial major depressive episodes, (b) anxiety syndromes prior to a first-lifetime major depressive episode, and (c) anxiety symptoms in childhood. Conclusion: Early anxiety symptoms and syndromes and agitated-mixed or psychotic initial depressive episodes predicted more long-term depressive morbidity in MDD.
2019
anxiety; depression; mixed; outcome; prediction; Adult; Age Factors; Aged; Anxiety Disorders; Child; Comorbidity; Correlation of Data; Depressive Disorder, Major; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Middle Aged; Prognosis; Psychotic Disorders; Risk Factors
01 Pubblicazione su rivista::01a Articolo in rivista
Early clinical predictors of long-term morbidity in major depressive disorder / Serra, G.; Koukopoulos, A.; De Chiara, L.; Koukopoulos, A. E.; Sani, G.; Tondo, L.; Girardi, P.; Reginaldi, D.; Baldessarini, R. J.. - In: EARLY INTERVENTION IN PSYCHIATRY. - ISSN 1751-7885. - 13:4(2019), pp. 999-1002. [10.1111/eip.12768]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1350713
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