Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis in somatic cells, with a special focus on the role of kinetochore factors. Then, we review evidence implicating mitotic apparatus- and kinetochore-resident factors in the origin of congenital microcephaly. We discuss data emerging from these works, which suggest a critical role of correct mitotic division in controlling neuronal cell proliferation and shaping the architecture of the central nervous system.

The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases / Degrassi, Francesca; Damizia, Michela; Lavia, Patrizia. - In: CELLS. - ISSN 2073-4409. - 9:1(2019), p. 49. [10.3390/cells9010049]

The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases

Degrassi, Francesca;Damizia, Michela;
2019

Abstract

Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis in somatic cells, with a special focus on the role of kinetochore factors. Then, we review evidence implicating mitotic apparatus- and kinetochore-resident factors in the origin of congenital microcephaly. We discuss data emerging from these works, which suggest a critical role of correct mitotic division in controlling neuronal cell proliferation and shaping the architecture of the central nervous system.
2019
chromosome segregation; kinetochore; microcephaly; mitotic apparatus; neural progenitors
01 Pubblicazione su rivista::01a Articolo in rivista
The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases / Degrassi, Francesca; Damizia, Michela; Lavia, Patrizia. - In: CELLS. - ISSN 2073-4409. - 9:1(2019), p. 49. [10.3390/cells9010049]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1347095
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