Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur and underlying mechanisms are still poorly understood. The aim of this study is to identify target genes within the tumor cells that might cause resistance to Olaparib. We focused on Neuropilin 1 (NRP1), a transmembrane receptor expressed in OC and correlated with poor survival, which has been also proposed as a key molecule in OC multidrug resistance.
MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1 / Vescarelli, Enrica; Gerini, Giulia; Megiorni, Francesca; Anastasiadou, Eleni; Pontecorvi, Paola; Solito, Luciana; De Vitis, Claudia; Camero, Simona; Marchetti, Claudia; Mancini, Rita; Benedetti Panici, Pierluigi; Dominici, Carlo; Romano, Ferdinando; Angeloni, Antonio; Marchese, Cinzia; Ceccarelli, Simona. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 39:1(2020), pp. 1-15. [10.1186/s13046-019-1490-7]
MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1
Vescarelli, Enrica;GERINI, GIULIA;Megiorni, Francesca;Anastasiadou, Eleni;Pontecorvi, Paola;De Vitis, Claudia;Camero, Simona;Marchetti, Claudia;Mancini, Rita;Benedetti Panici, Pierluigi;Dominici, Carlo;Romano, Ferdinando;Angeloni, Antonio;Marchese, Cinzia;Ceccarelli, Simona
2020
Abstract
Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur and underlying mechanisms are still poorly understood. The aim of this study is to identify target genes within the tumor cells that might cause resistance to Olaparib. We focused on Neuropilin 1 (NRP1), a transmembrane receptor expressed in OC and correlated with poor survival, which has been also proposed as a key molecule in OC multidrug resistance.| File | Dimensione | Formato | |
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