Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.

Targeting microRNAs as a therapeutic strategy to reduce oxidative stress in diabetes / Grieco, Giuseppina Emanuela; Brusco, Noemi; Licata, Giada; Nigi, Laura; Formichi, Caterina; Dotta, Francesco; Sebastiani, Guido. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 20:24(2019). [10.3390/ijms20246358]

Targeting microRNAs as a therapeutic strategy to reduce oxidative stress in diabetes

Nigi, Laura;Formichi, Caterina;
2019

Abstract

Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.
2019
aptamers; diabetes; drug delivery; miRNAs; nanoparticles; oxidative stress
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Targeting microRNAs as a therapeutic strategy to reduce oxidative stress in diabetes / Grieco, Giuseppina Emanuela; Brusco, Noemi; Licata, Giada; Nigi, Laura; Formichi, Caterina; Dotta, Francesco; Sebastiani, Guido. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 20:24(2019). [10.3390/ijms20246358]
File allegati a questo prodotto
File Dimensione Formato  
Grieco_Targeting-microRNAs_2019.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.03 MB
Formato Adobe PDF
2.03 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1346132
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 24
social impact