Background: Gastro-oesophageal reflux is very common in the paediatric age group. There is no single and reliable test to distinguish between physiologic and pathological gastro-oesophageal reflux, and this lack of clear distinction between disease and normal can have a negative impact on the management of children. Aims: To evaluate the usefulness of 24-h oesophageal pH-impedance study in infants and children with suspected gastro-oesophageal reflux disease. Methods: Patients were classified by age groups (A–C) and reflux-related symptoms (typical and atypical). All underwent pH-impedance study. If the latter suggested an abnormal reflux, patients received therapy in accordance with NASPGHAN/ESPGHAN recommendations, while those with normal study had an additional diagnostic work-up. The efficacy of therapy was evaluated with a specific standardized questionnaire for different ages. Results: The study was abnormal in 203/428 patients (47%) while normal in 225/428 (53%). Of those with abnormal study, 109 exhibited typical symptoms (54%), and 94 atypical (46%). The great majority of the patients with abnormal study were responsive to medical anti-reflux therapy. Conclusions: We confirm the utility of prolonged oesophageal pH-impedance study in detecting gastro-oesophageal reflux disease in children and in guiding therapy. Performing oesophageal pH-impedance monitoring in children with suspected gastro-oesophageal reflux disease is helpful to establish the diagnosis and avoid unnecessary therapy.

Combined multichannel intraluminal impedance and pH monitoring is helpful in managing children with suspected gastro-oesophageal reflux disease / Rossi, P.; Isoldi, S.; Mallardo, S.; Papoff, P.; Rossetti, D.; Dilillo, A.; Oliva, S.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 50:9(2018), pp. 910-915. [10.1016/j.dld.2018.03.031]

Combined multichannel intraluminal impedance and pH monitoring is helpful in managing children with suspected gastro-oesophageal reflux disease

Rossi P.
Primo
Conceptualization
;
Isoldi S.
Secondo
Writing – Original Draft Preparation
;
Mallardo S.
Investigation
;
Papoff P.
Investigation
;
Rossetti D.
Investigation
;
Dilillo A.
Penultimo
Investigation
;
Oliva S.
Ultimo
Writing – Review & Editing
2018

Abstract

Background: Gastro-oesophageal reflux is very common in the paediatric age group. There is no single and reliable test to distinguish between physiologic and pathological gastro-oesophageal reflux, and this lack of clear distinction between disease and normal can have a negative impact on the management of children. Aims: To evaluate the usefulness of 24-h oesophageal pH-impedance study in infants and children with suspected gastro-oesophageal reflux disease. Methods: Patients were classified by age groups (A–C) and reflux-related symptoms (typical and atypical). All underwent pH-impedance study. If the latter suggested an abnormal reflux, patients received therapy in accordance with NASPGHAN/ESPGHAN recommendations, while those with normal study had an additional diagnostic work-up. The efficacy of therapy was evaluated with a specific standardized questionnaire for different ages. Results: The study was abnormal in 203/428 patients (47%) while normal in 225/428 (53%). Of those with abnormal study, 109 exhibited typical symptoms (54%), and 94 atypical (46%). The great majority of the patients with abnormal study were responsive to medical anti-reflux therapy. Conclusions: We confirm the utility of prolonged oesophageal pH-impedance study in detecting gastro-oesophageal reflux disease in children and in guiding therapy. Performing oesophageal pH-impedance monitoring in children with suspected gastro-oesophageal reflux disease is helpful to establish the diagnosis and avoid unnecessary therapy.
2018
diagnosis; gastro-oesophageal reflux disease; pH-impedance monitoring; proton pump inhibitors; adolescent; analysis of variance; child; child, preschool; esophageal pH Monitoring; female; gastroesophageal reflux; humans; infant; male; prospective studies; proton pump inhibitors; surveys and questionnaires; electric impedance
01 Pubblicazione su rivista::01a Articolo in rivista
Combined multichannel intraluminal impedance and pH monitoring is helpful in managing children with suspected gastro-oesophageal reflux disease / Rossi, P.; Isoldi, S.; Mallardo, S.; Papoff, P.; Rossetti, D.; Dilillo, A.; Oliva, S.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 50:9(2018), pp. 910-915. [10.1016/j.dld.2018.03.031]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1343689
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