BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. Here we demonstrate that BRCA2 deletion triggers TERRA hyperexpression and alternative lengthening mechanisms (ALT) in colon cancer cells in presence of telomerase activity. This finding opens the question if cancer patients bearing BRCA2 germline or sporadic mutation are suitable for anti-telomerase therapies, or how ALT activation could influence the short or long-term response to anti-PARP inhibitors or anti-G-quadruplex therapies.

BRCA2 deletion induces alternative lengthening of telomeres in telomerase positive colon cancer cells / Luca, Pompili; Maresca, Carmen; DELLO STRITTO, Angela; Annamaria, Biroccio; Erica, Salvati. - In: GENES. - ISSN 2073-4425. - (2019).

BRCA2 deletion induces alternative lengthening of telomeres in telomerase positive colon cancer cells

MARESCA, CARMEN;DELLO STRITTO, ANGELA;
2019

Abstract

BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. Here we demonstrate that BRCA2 deletion triggers TERRA hyperexpression and alternative lengthening mechanisms (ALT) in colon cancer cells in presence of telomerase activity. This finding opens the question if cancer patients bearing BRCA2 germline or sporadic mutation are suitable for anti-telomerase therapies, or how ALT activation could influence the short or long-term response to anti-PARP inhibitors or anti-G-quadruplex therapies.
2019
ALT; BRCA2 mutation; telomeres.
01 Pubblicazione su rivista::01a Articolo in rivista
BRCA2 deletion induces alternative lengthening of telomeres in telomerase positive colon cancer cells / Luca, Pompili; Maresca, Carmen; DELLO STRITTO, Angela; Annamaria, Biroccio; Erica, Salvati. - In: GENES. - ISSN 2073-4425. - (2019).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1343591
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