Purpose: High cholesterol levels in untreated familial hypercholesterolemia (FH) can significantly compromise retinal microvasculature. This type of dyslipidemia is commonly treated with combination drug therapy and lipoprotein apheresis (LA). We conducted a retrospective observational study by means of optical coherence tomography (OCT) and optical coherence tomography-angiography (OCTA) on patients affected by familial hypercholesterolemia (FH) treated by LA and healthy controls. Methods: A group of 20 patients (40 eyes; 8 males and 12 females; mean age±SD: 50, 05±13, 68) with FH were compared to a group of 20 matched healthy controls (CT group). Inclusion criteria: genetically-confirmed diagnosis of FH, treatment with combination drug therapy and LA for at least 2 years, spherical equivalent (SE)-3 to+ 3 diopters. Exclusion criteria: pre-existent retinal or choroidal damage (including macular
Familial hypercholesterolaemia: the influence of lipoprotein apheresis on choroid and retina. an oct and octa retrospective study / Pacella, Elena; Pannarale, Luigi; Pacella, Fernanda; Trovato Battagliola, Edoardo; Forastiere, Michele; Stefanutti, Claudia. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - 60:9(2019), pp. 4576-4576. (Intervento presentato al convegno Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) tenutosi a Vancouver, Canada).
Familial hypercholesterolaemia: the influence of lipoprotein apheresis on choroid and retina. an oct and octa retrospective study
Elena Pacella
Primo
;Luigi PannaraleSecondo
;Fernanda Pacella;Michele Forastiere;Claudia Stefanutti
2019
Abstract
Purpose: High cholesterol levels in untreated familial hypercholesterolemia (FH) can significantly compromise retinal microvasculature. This type of dyslipidemia is commonly treated with combination drug therapy and lipoprotein apheresis (LA). We conducted a retrospective observational study by means of optical coherence tomography (OCT) and optical coherence tomography-angiography (OCTA) on patients affected by familial hypercholesterolemia (FH) treated by LA and healthy controls. Methods: A group of 20 patients (40 eyes; 8 males and 12 females; mean age±SD: 50, 05±13, 68) with FH were compared to a group of 20 matched healthy controls (CT group). Inclusion criteria: genetically-confirmed diagnosis of FH, treatment with combination drug therapy and LA for at least 2 years, spherical equivalent (SE)-3 to+ 3 diopters. Exclusion criteria: pre-existent retinal or choroidal damage (including macularI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
