New tubulin and NHERF1 targeting anticancer agents

The thesis focused on the discovery of novel chemical entities with therapeutic activity. The results presented in this manuscript are divided into three parts and were conducted in Sapienza University – Rome (Part 1-2) and Cardiff University – UK (part 3). The first part contains a set of results on the synthesis and biological evaluation of novel indole and pyrrole derivatives as tubulin polymerization inhibitors. The second part discusses the synthesis of new NHERF1 antagonists in the treatment of colorectal cancer. In the last part, are briefly described the synthesis and biological evaluation of novel inhibitors of Norovirus RNA-dependent RNA polymerase.