Multivisceral resection in locally advanced colorectal cancer: analysis of associated humoral and clinical factors

Colorectal cancer is locally advanced in 10-20% of cases. In these cases the surgical procedure of multivisceral resection is used in an attempt to obtain a curative result. The aim of the present study was to assess survival and biological humoral and clinical factors in patients subjected to multivisceral resection in our surgical unit. Fifteen patients affected by advanced colorectal cancer (T4) subjected to multivisceral resection are compared with a population of 19 patients subjected to standard resection for Dukes B and C colorectal cancer. We analysed three-year survival and the associated clinical, humoral and biological factors. Survival analysis was done using Kaplan-Meyer curves. The three-year survival rate was 33% in patients subjected to multivisceral resection. Post-surgical mortality (< 30 days) was 6.6%. Longer surgical times, a greater number of transfusions and high values of CEA, CA 19.9, and total bilirubin are statistically associated with the group of patients subjected to multivisceral resection. In advanced colorectal cancer multivisceral resection appears to be a legitimate procedure in order to obtain presumed oncological radicality. The identification of predictive factors can select patients most likely to benefit from multivisceral resection.