In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using 'androgen receptor or AR', 'testosterone', 'bladder cancer' and 'non-muscle invasive bladder cancer or NMIBC' as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients' gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored.

Role of androgen receptor expression in non-muscle-invasive bladder cancer. A systematic review and meta-analysis / Francesca, Sanguedolce; Luigi, Cormio; Giuseppe, Carrieri; Beppe, Calò; Russo, Davide; Andrea, Menin; Pastore, ANTONIO LUIGI; Greco, Francesco; Giorgio, Bozzini; Antonio, Galfano; Giovannalberto, Pini; Angelo, Porreca; Filippo, Mugavero; Falsaperla, Mario; Carlo, Ceruti; Luca, Cindolo; Alessandro Antonelli and Andrea Minervini,. - In: HISTOLOGY AND HISTOPATHOLOGY. - ISSN 1699-5848. - (2019), pp. 1-13. [10.14670/HH-18-189]

Role of androgen receptor expression in non-muscle-invasive bladder cancer. A systematic review and meta-analysis

RUSSO, DAVIDE;Antonio Luigi Pastore;Francesco Greco;Mario Falsaperla;
2019

Abstract

In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using 'androgen receptor or AR', 'testosterone', 'bladder cancer' and 'non-muscle invasive bladder cancer or NMIBC' as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients' gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1340588
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