Extracellular vesicles (EVs) are released by different cell types in- cluding mast cells (MCs) and are involved in intercellular communication thanks to their complex cargo of bioactive molecules. Among them, exosomes represent nanovesicles (<150 nm) secreted from endosomal compartments upon their fusion with the plasma membrane. Through both constitutive and induced exocytosis, MCs release exosomes that deliver several molecules including mRNA/miRNA and subunits of the high-affinity IgE receptor (FcεRI). However, the role of MC-derived vesicles in the context of allergic reactions is still controversial. A recent study provides evidence that exosomes re- leased from unstimulated mouse bone marrow-derived mast cells (mBMMCs) bind to free IgE and decrease circulating IgE levels, thus inhibiting the allergic response. In contrast, several evidences support a positive regulatory role of MC-derived exosomes, suggesting that depending on MC activation status they can either attenuate or stimulate the inflammatory responses.
Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation / Molfetta, Rosa; Lecce, Mario; Quatrini, Linda; Caracciolo, Giulio; Digiacomo, Luca; Masuelli, Laura; Milito, Nadia Domenica; Vulpis, Elisabetta; Zingoni, Alessandra; Galandrini, Ricciarda; Santoni, Angela; Paolini, Rossella. - In: ALLERGY. - ISSN 1398-9995. - 75:5(2020), pp. 1260-1263. [10.1111/all.14103]
Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation
Molfetta, RosaCo-primo
;Lecce, MarioCo-primo
;Quatrini, Linda;Caracciolo, Giulio;Digiacomo, Luca;Masuelli, Laura;Milito, Nadia Domenica;Vulpis, Elisabetta;Zingoni, Alessandra;Galandrini, Ricciarda;Santoni, Angela;Paolini, Rossella
2020
Abstract
Extracellular vesicles (EVs) are released by different cell types in- cluding mast cells (MCs) and are involved in intercellular communication thanks to their complex cargo of bioactive molecules. Among them, exosomes represent nanovesicles (<150 nm) secreted from endosomal compartments upon their fusion with the plasma membrane. Through both constitutive and induced exocytosis, MCs release exosomes that deliver several molecules including mRNA/miRNA and subunits of the high-affinity IgE receptor (FcεRI). However, the role of MC-derived vesicles in the context of allergic reactions is still controversial. A recent study provides evidence that exosomes re- leased from unstimulated mouse bone marrow-derived mast cells (mBMMCs) bind to free IgE and decrease circulating IgE levels, thus inhibiting the allergic response. In contrast, several evidences support a positive regulatory role of MC-derived exosomes, suggesting that depending on MC activation status they can either attenuate or stimulate the inflammatory responses.File | Dimensione | Formato | |
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