Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in adults and children. Along with obesity, diabetes and insulin resistance, genetic factors strongly impact on NAFLD development and progression. Dysregulated bile acid metabolism and the fibroblast growth factor 19 (FGF19) pathway play a pivotal role in NAFLD pathogenesis. However, it remains to be defined the mechanism through which the FGF19 receptor system is associated with liver damage in NAFLD.

β-Klotho gene variation is associated with liver damage in children with NAFLD / Dongiovanni, Paola; Crudele, Annalisa; Panera, Nadia; Romito, Ilaria; Meroni, Marica; De Stefanis, Cristiano; Palma, Alessia; Comparcola, Donatella; Fracanzani, Anna Ludovica; Miele, Luca; Valenti, Luca; Nobili, Valerio; Alisi, Anna. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2019). [10.1016/j.jhep.2019.10.011]

β-Klotho gene variation is associated with liver damage in children with NAFLD

Panera, Nadia;Romito, Ilaria;Miele, Luca;Alisi, Anna
2019

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in adults and children. Along with obesity, diabetes and insulin resistance, genetic factors strongly impact on NAFLD development and progression. Dysregulated bile acid metabolism and the fibroblast growth factor 19 (FGF19) pathway play a pivotal role in NAFLD pathogenesis. However, it remains to be defined the mechanism through which the FGF19 receptor system is associated with liver damage in NAFLD.
2019
NAFLD; SNPs; ballooning; inflammation; β-Klotho
01 Pubblicazione su rivista::01a Articolo in rivista
β-Klotho gene variation is associated with liver damage in children with NAFLD / Dongiovanni, Paola; Crudele, Annalisa; Panera, Nadia; Romito, Ilaria; Meroni, Marica; De Stefanis, Cristiano; Palma, Alessia; Comparcola, Donatella; Fracanzani, Anna Ludovica; Miele, Luca; Valenti, Luca; Nobili, Valerio; Alisi, Anna. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2019). [10.1016/j.jhep.2019.10.011]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1338245
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