The alteration of the DNA methylation pattern is often related to the onset of diseases based on epigenetic dysregulation, primarily cancer. In this scenery the development of DNA methyltransferase inhibitors is one of the most attractive challenges for anticancer therapy. The present chapter proposes a comprehensive classification of the DNA methyltransferase inhibitors known in literature, on the basis of their natural or synthetic nature and their mechanism of action.

DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation / Lucidi, Alessia; Tomaselli, Daniela; Rotili, Dante; Mai, Antonello. - (2019), pp. 295-331. - RNA TECHNOLOGIES. [10.1007/978-3-030-14792-1].

DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation

Alessia Lucidi;Daniela Tomaselli;Dante Rotili
;
Antonello Mai
2019

Abstract

The alteration of the DNA methylation pattern is often related to the onset of diseases based on epigenetic dysregulation, primarily cancer. In this scenery the development of DNA methyltransferase inhibitors is one of the most attractive challenges for anticancer therapy. The present chapter proposes a comprehensive classification of the DNA methyltransferase inhibitors known in literature, on the basis of their natural or synthetic nature and their mechanism of action.
2019
The DNA, RNA, and Histone Methylomes
978-3-030-14791-4
978-3-030-14792-1
Epigenetics; DNA methyltransferase; DNMT inhibitors; Anticancer therapy; Tumor suppressor genes
02 Pubblicazione su volume::02a Capitolo o Articolo
DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation / Lucidi, Alessia; Tomaselli, Daniela; Rotili, Dante; Mai, Antonello. - (2019), pp. 295-331. - RNA TECHNOLOGIES. [10.1007/978-3-030-14792-1].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1336760
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