This short communication reports the preliminary results of Fecal Microbial Transplantation (FMT) impact on microbiota, microbial translocation (MT), and immune activation in four recurrent Clostridium difficile infection (R-CDI) patients. After FMT a restore of gut microbiota composition with a significant increase of fecal acetyl-putrescine and spermidine and fecal acetate and butyrate, a decrease of immune activation of T cells CD4+ and CD8+levels, and of LPS binding protein (LBP) level, were observed. Preliminary results indicate that FMT seems to be helpful not only as a CDI radical cure, with an impact on fecal microbiota and metabolome profiles, but also on MT and immune activation.

Fecal microbial transplantation impact on gut microbiota composition and metabolome, microbial translocation and T-lymphocyte immune activation in recurrent clostridium difficile infection patients / Bruno, G.; Gagliardi, A.; Oliva, A.; Trancassini, M.; Macone, A.; Cicerone, C.; D'Abramo, A.; Iebba, V.; Auria, S.; Bonfiglio, G.; Zingaropoli, M. A.; D'Ettorre, G.; Badiali, D.; Vullo, V.; Corazziari, E. S.; Schippa, S.. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 42:4(2019), pp. 221-224.

Fecal microbial transplantation impact on gut microbiota composition and metabolome, microbial translocation and T-lymphocyte immune activation in recurrent clostridium difficile infection patients

Bruno G.;Oliva A.;Trancassini M.;Macone A.;Cicerone C.;D'Abramo A.;Iebba V.;Bonfiglio G.;Zingaropoli M. A.;D'Ettorre G.;Badiali D.;Vullo V.;Corazziari E. S.;Schippa S.
Ultimo
2019

Abstract

This short communication reports the preliminary results of Fecal Microbial Transplantation (FMT) impact on microbiota, microbial translocation (MT), and immune activation in four recurrent Clostridium difficile infection (R-CDI) patients. After FMT a restore of gut microbiota composition with a significant increase of fecal acetyl-putrescine and spermidine and fecal acetate and butyrate, a decrease of immune activation of T cells CD4+ and CD8+levels, and of LPS binding protein (LBP) level, were observed. Preliminary results indicate that FMT seems to be helpful not only as a CDI radical cure, with an impact on fecal microbiota and metabolome profiles, but also on MT and immune activation.
2019
fecal microbiota transplantation; gut microbiota; metabolome; microbial translocation; recurrent clostridium difficile infection; T-cell activation
01 Pubblicazione su rivista::01a Articolo in rivista
Fecal microbial transplantation impact on gut microbiota composition and metabolome, microbial translocation and T-lymphocyte immune activation in recurrent clostridium difficile infection patients / Bruno, G.; Gagliardi, A.; Oliva, A.; Trancassini, M.; Macone, A.; Cicerone, C.; D'Abramo, A.; Iebba, V.; Auria, S.; Bonfiglio, G.; Zingaropoli, M. A.; D'Ettorre, G.; Badiali, D.; Vullo, V.; Corazziari, E. S.; Schippa, S.. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 42:4(2019), pp. 221-224.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1335454
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