This short communication reports the preliminary results of Fecal Microbial Transplantation (FMT) impact on microbiota, microbial translocation (MT), and immune activation in four recurrent Clostridium difficile infection (R-CDI) patients. After FMT a restore of gut microbiota composition with a significant increase of fecal acetyl-putrescine and spermidine and fecal acetate and butyrate, a decrease of immune activation of T cells CD4+ and CD8+levels, and of LPS binding protein (LBP) level, were observed. Preliminary results indicate that FMT seems to be helpful not only as a CDI radical cure, with an impact on fecal microbiota and metabolome profiles, but also on MT and immune activation.
Fecal microbial transplantation impact on gut microbiota composition and metabolome, microbial translocation and T-lymphocyte immune activation in recurrent clostridium difficile infection patients / Bruno, G.; Gagliardi, A.; Oliva, A.; Trancassini, M.; Macone, A.; Cicerone, C.; D'Abramo, A.; Iebba, V.; Auria, S.; Bonfiglio, G.; Zingaropoli, M. A.; D'Ettorre, G.; Badiali, D.; Vullo, V.; Corazziari, E. S.; Schippa, S.. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 42:4(2019), pp. 221-224.
Fecal microbial transplantation impact on gut microbiota composition and metabolome, microbial translocation and T-lymphocyte immune activation in recurrent clostridium difficile infection patients
Bruno G.;Oliva A.;Trancassini M.;Macone A.;Cicerone C.;D'Abramo A.;Iebba V.;Bonfiglio G.;Zingaropoli M. A.;D'Ettorre G.;Badiali D.;Vullo V.;Corazziari E. S.;Schippa S.
Ultimo
2019
Abstract
This short communication reports the preliminary results of Fecal Microbial Transplantation (FMT) impact on microbiota, microbial translocation (MT), and immune activation in four recurrent Clostridium difficile infection (R-CDI) patients. After FMT a restore of gut microbiota composition with a significant increase of fecal acetyl-putrescine and spermidine and fecal acetate and butyrate, a decrease of immune activation of T cells CD4+ and CD8+levels, and of LPS binding protein (LBP) level, were observed. Preliminary results indicate that FMT seems to be helpful not only as a CDI radical cure, with an impact on fecal microbiota and metabolome profiles, but also on MT and immune activation.File | Dimensione | Formato | |
---|---|---|---|
Bruno_Fecal microbial transplantation_2019.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
676.66 kB
Formato
Adobe PDF
|
676.66 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.