Lamins A and C are intermediate filaments that provide structural support to the nuclear envelope and regulate gene expression. In this issue, Bertero et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902117) report that although lamin A/C haploinsufficient cardiomyocytes show disease-associated phenotypes, those changes cannot be explained by alterations in chromatin compartmentalization.
Challenging the "chromatin hypothesis" of cardiac laminopathies with LMNA mutant iPS cells / Mozzetta, C.; Tedesco, F. S.. - In: THE JOURNAL OF CELL BIOLOGY. - ISSN 0021-9525. - 218:9(2019), pp. 2826-2828. [10.1083/jcb.201907166]
Challenging the "chromatin hypothesis" of cardiac laminopathies with LMNA mutant iPS cells
Mozzetta C.
Primo
;
2019
Abstract
Lamins A and C are intermediate filaments that provide structural support to the nuclear envelope and regulate gene expression. In this issue, Bertero et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902117) report that although lamin A/C haploinsufficient cardiomyocytes show disease-associated phenotypes, those changes cannot be explained by alterations in chromatin compartmentalization.| File | Dimensione | Formato | |
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