Insight into the pathogenesis of very early onset-inflammatory bowel disease (VEO-IBD) has expanded through the identification of causative monogenic defects detected in a subset of patients. However, the clinical course of this population remains uncertain. The study objective is to determine whether VEO-IBD is associated with more severe disease, defined as increased surgical intervention and growth failure, than older pediatric IBD. Secondary outcomes included therapeutic response and hospitalizations.
The Unique Disease Course of Children with Very Early Onset-Inflammatory Bowel Disease / Kelsen, Judith R; Conrad, Maire A; Dawany, Noor; Patel, Trusha; Shraim, Rawan; Merz, Audrey; Maurer, Kelly; Sullivan, Kathleen E; Devoto, Marcella. - In: INFLAMMATORY BOWEL DISEASES. - ISSN 1078-0998. - (2019). [10.1093/ibd/izz214]
The Unique Disease Course of Children with Very Early Onset-Inflammatory Bowel Disease
Devoto, Marcella
2019
Abstract
Insight into the pathogenesis of very early onset-inflammatory bowel disease (VEO-IBD) has expanded through the identification of causative monogenic defects detected in a subset of patients. However, the clinical course of this population remains uncertain. The study objective is to determine whether VEO-IBD is associated with more severe disease, defined as increased surgical intervention and growth failure, than older pediatric IBD. Secondary outcomes included therapeutic response and hospitalizations.| File | Dimensione | Formato | |
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