Intrahepatic cholangiocarcinoma (iCCA) is a malignancy that arises from the intrahepatic biliary tree, showing high mortality rates due to its late clinical presentation and limited treatment options. iCCA is characterized by a dense, reactive desmoplastic stroma marked by a dramatic accumulation of extracellular matrix (ECM). Although recent results strongly suggest a relationship between increasing desmoplastic stroma and the enhanced malignant behaviour of iCCA, the importance of ECM proteins in the pathogenesis of iCCA still have to be addressed.

Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure / Carpino, Guido; Overi, Diletta; Melandro, Fabio; Grimaldi, Alessio; Cardinale, Vincenzo; Di Matteo, Sabina; Mennini, Gianluca; Rossi, Massimo; Alvaro, Domenico; Barnaba, Vincenzo; Gaudio, Eugenio; Mancone, Carmine. - In: CLINICAL PROTEOMICS. - ISSN 1559-0275. - 16:(2019), pp. 1-12. [10.1186/s12014-019-9257-x]

Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure

Carpino, Guido;Overi, Diletta;Melandro, Fabio;GRIMALDI, ALESSIO;Cardinale, Vincenzo;Di Matteo, Sabina;Mennini, Gianluca;Rossi, Massimo;Alvaro, Domenico;Barnaba, Vincenzo;Gaudio, Eugenio;Mancone, Carmine
2019

Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a malignancy that arises from the intrahepatic biliary tree, showing high mortality rates due to its late clinical presentation and limited treatment options. iCCA is characterized by a dense, reactive desmoplastic stroma marked by a dramatic accumulation of extracellular matrix (ECM). Although recent results strongly suggest a relationship between increasing desmoplastic stroma and the enhanced malignant behaviour of iCCA, the importance of ECM proteins in the pathogenesis of iCCA still have to be addressed.
2019
cholangiocarcinoma; collagen type III, COL3A1; desmoplastic stroma; matrisome
01 Pubblicazione su rivista::01a Articolo in rivista
Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure / Carpino, Guido; Overi, Diletta; Melandro, Fabio; Grimaldi, Alessio; Cardinale, Vincenzo; Di Matteo, Sabina; Mennini, Gianluca; Rossi, Massimo; Alvaro, Domenico; Barnaba, Vincenzo; Gaudio, Eugenio; Mancone, Carmine. - In: CLINICAL PROTEOMICS. - ISSN 1559-0275. - 16:(2019), pp. 1-12. [10.1186/s12014-019-9257-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1327741
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