The use of synthetic DNA to design and build molecular machines and well-defined structures at the nanoscale has greatly impacted the field of nanotechnology. Here we expand the current toolkit in this field by demonstrating an efficient, quantitative, and versatile approach that allows us to remotely control DNA-based reactions and DNA nanostructure self-assembly using electronic inputs. To do so we have deposited onto the surface of disposable chips different DNA input strands that upon the application of a cathodic potential can be desorbed in a remote and controlled way and trigger DNA-based reactions and DNA nanostructure self-assembly. We demonstrate that this effect is specific and versatile and allows the orthogonal control of multiple reactions and multiple structures in the same solution. Moreover, the strategy is highly tunable and can be finely modulated by varying the cathodic potential, the period of applied potential, and the density of the DNA strand on the chip surface. Our approach thus represents a versatile way to remotely control DNA-based circuits and nanostructure assembly and can allow new possible applications of DNA-based nanotools.

Remote Electronic Control of DNA-Based Reactions and Nanostructure Assembly / Amodio, A.; Del Grosso, E.; Troina, A.; Placidi, E.; Ricci, F.. - In: NANO LETTERS. - ISSN 1530-6984. - 18:5(2018), pp. 2918-2923. [10.1021/acs.nanolett.8b00179]

Remote Electronic Control of DNA-Based Reactions and Nanostructure Assembly

Placidi E.;
2018

Abstract

The use of synthetic DNA to design and build molecular machines and well-defined structures at the nanoscale has greatly impacted the field of nanotechnology. Here we expand the current toolkit in this field by demonstrating an efficient, quantitative, and versatile approach that allows us to remotely control DNA-based reactions and DNA nanostructure self-assembly using electronic inputs. To do so we have deposited onto the surface of disposable chips different DNA input strands that upon the application of a cathodic potential can be desorbed in a remote and controlled way and trigger DNA-based reactions and DNA nanostructure self-assembly. We demonstrate that this effect is specific and versatile and allows the orthogonal control of multiple reactions and multiple structures in the same solution. Moreover, the strategy is highly tunable and can be finely modulated by varying the cathodic potential, the period of applied potential, and the density of the DNA strand on the chip surface. Our approach thus represents a versatile way to remotely control DNA-based circuits and nanostructure assembly and can allow new possible applications of DNA-based nanotools.
2018
DNA nanotechnology; DNA origami; electronic; nucleic acids; self-assembly; DNA; Electrodes; Electronics; Equipment Design; Nanostructures; Nanotechnology; Nucleic Acid Conformation; Robotics
01 Pubblicazione su rivista::01a Articolo in rivista
Remote Electronic Control of DNA-Based Reactions and Nanostructure Assembly / Amodio, A.; Del Grosso, E.; Troina, A.; Placidi, E.; Ricci, F.. - In: NANO LETTERS. - ISSN 1530-6984. - 18:5(2018), pp. 2918-2923. [10.1021/acs.nanolett.8b00179]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1325906
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