The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.
A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin / Benkerrou, D.; Minicozzi, V.; Gradogna, A.; Milenkovic, S.; Bodrenko, I. V.; Festa, M.; Lagostena, L.; Cornara, L.; D'Amore, A.; Ceccarelli, M.; Filippini, A.; Carpaneto, A.. - In: BIOPHYSICAL CHEMISTRY. - ISSN 0301-4622. - 254:(2019), pp. 1-6. [10.1016/j.bpc.2019.106246]
A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin
D'Amore, A.;Filippini, A.;
2019
Abstract
The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.| File | Dimensione | Formato | |
|---|---|---|---|
|
Benkerrou_Perspective_2019.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
1.04 MB
Formato
Adobe PDF
|
1.04 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
