Satellite cells (SCs) are muscle stem cells that remain quiescent during homeostasis and are activated in response to acute muscle damage or in chronic degenerative conditions such as Duchenne Muscular Dystrophy. The activity of SCs is supported by specialized cells which either reside in the muscle or are recruited in regenerating skeletal muscles, such as for instance macrophages (MΦs). By using a dystrophic mouse model of transient MΦ depletion, we describe a shift in identity of muscle stem cells dependent on the crosstalk between MΦs and SCs. Indeed MΦ depletion determines adipogenic conversion of SCs and exhaustion of the SC pool leading to an exacerbated dystrophic phenotype. The reported data could also provide new insights into therapeutic approaches targeting inflammation in dystrophic muscles.

Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice / Madaro, Luca; Torcinaro, Alessio; De Bardi, Marco; Contino, Federica F; Pelizzola, Mattia; Diaferia, Giuseppe R; Imeneo, Giulia; Bouchè, Marina; Puri, Pier Lorenzo; De Santa, Francesca. - In: PLOS GENETICS. - ISSN 1553-7404. - 15:10(2019), pp. 1-29. [10.1371/journal.pgen.1008408]

Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice

Madaro, Luca;Bouchè, Marina;
2019

Abstract

Satellite cells (SCs) are muscle stem cells that remain quiescent during homeostasis and are activated in response to acute muscle damage or in chronic degenerative conditions such as Duchenne Muscular Dystrophy. The activity of SCs is supported by specialized cells which either reside in the muscle or are recruited in regenerating skeletal muscles, such as for instance macrophages (MΦs). By using a dystrophic mouse model of transient MΦ depletion, we describe a shift in identity of muscle stem cells dependent on the crosstalk between MΦs and SCs. Indeed MΦ depletion determines adipogenic conversion of SCs and exhaustion of the SC pool leading to an exacerbated dystrophic phenotype. The reported data could also provide new insights into therapeutic approaches targeting inflammation in dystrophic muscles.
2019
macrophages; muscular dystrophy; satellite cells
01 Pubblicazione su rivista::01a Articolo in rivista
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice / Madaro, Luca; Torcinaro, Alessio; De Bardi, Marco; Contino, Federica F; Pelizzola, Mattia; Diaferia, Giuseppe R; Imeneo, Giulia; Bouchè, Marina; Puri, Pier Lorenzo; De Santa, Francesca. - In: PLOS GENETICS. - ISSN 1553-7404. - 15:10(2019), pp. 1-29. [10.1371/journal.pgen.1008408]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1322564
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