Differentiation of infection from aseptic inflammation represents a major clinical issue. None of the commercially available compounds (labeled granulocytes, antigranulocyte antibodies, Ga-citrate, labeled immunoglobulin G, F-FDG) is capable of this differentiation, producing a nonnegligible false-positive rate. Recently, our group reported on a reliable labeling procedure of the antimicrobial peptide human β-defensin 3 (HBD-3) with Tc. The aim of this study was to evaluate in vivo Tc-HBD-3 uptake in a rat model of infection.

In vivo microbial targeting of 99mTc-Labeled Human β-Defensin-3 in a rat model of infection / Follacchio, Giulia Anna; Pala, Alessandro; Scaccianoce, Sergio; Monteleone, Francesco; Colletti, Patrick M; Rubello, Domenico; Liberatore, Mauro. - In: CLINICAL NUCLEAR MEDICINE. - ISSN 0363-9762. - 44:11(2019), pp. e602-e606. [10.1097/RLU.0000000000002713]

In vivo microbial targeting of 99mTc-Labeled Human β-Defensin-3 in a rat model of infection

Follacchio, Giulia Anna;Pala, Alessandro;Scaccianoce, Sergio;Monteleone, Francesco;Liberatore, Mauro
2019

Abstract

Differentiation of infection from aseptic inflammation represents a major clinical issue. None of the commercially available compounds (labeled granulocytes, antigranulocyte antibodies, Ga-citrate, labeled immunoglobulin G, F-FDG) is capable of this differentiation, producing a nonnegligible false-positive rate. Recently, our group reported on a reliable labeling procedure of the antimicrobial peptide human β-defensin 3 (HBD-3) with Tc. The aim of this study was to evaluate in vivo Tc-HBD-3 uptake in a rat model of infection.
2019
99mTc; antimicrobial peptides; human defensin; infection; inflammation
01 Pubblicazione su rivista::01a Articolo in rivista
In vivo microbial targeting of 99mTc-Labeled Human β-Defensin-3 in a rat model of infection / Follacchio, Giulia Anna; Pala, Alessandro; Scaccianoce, Sergio; Monteleone, Francesco; Colletti, Patrick M; Rubello, Domenico; Liberatore, Mauro. - In: CLINICAL NUCLEAR MEDICINE. - ISSN 0363-9762. - 44:11(2019), pp. e602-e606. [10.1097/RLU.0000000000002713]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1320089
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