Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages / Petruccioli, Elisa; Romagnoli, Alessandra; Corazzari, Marco; Coccia, Eliana M; Butera, Ornella; Delogu, Giovanni; Piacentini, Mauro; Girardi, Enrico; Fimia, Gian Maria; Goletti, Delia. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 205:9(2012), pp. 1425-1435. [10.1093/infdis/jis226]

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

FIMIA, Gian Maria;
2012

Abstract

Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.
2012
Adaptor Proteins; Signal Transducing; Autophagy; Blotting; Western; Cell Communication; Humans; Interferon-gamma; Macrophages; Microscopy; Confocal; Mycobacterium tuberculosis; Phagosomes; Real-Time Polymerase Chain Reaction; Stem Cells; T-Lymphocytes; Tuberculosis; Tumor Necrosis Factor-alpha
01 Pubblicazione su rivista::01a Articolo in rivista
Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages / Petruccioli, Elisa; Romagnoli, Alessandra; Corazzari, Marco; Coccia, Eliana M; Butera, Ornella; Delogu, Giovanni; Piacentini, Mauro; Girardi, Enrico; Fimia, Gian Maria; Goletti, Delia. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 205:9(2012), pp. 1425-1435. [10.1093/infdis/jis226]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1319195
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