Metastatic melanoma is characterized by extremely poor survival rates and hence novel therapies are urgently required. The ability of many anticancer drugs to activate autophagy, a lysosomal-mediated catabolic process which usually promotes cell survival, suggests targeting the autophagy pathway may be a novel means to augment therapy.

Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition / Armstrong, Jane L; Corazzari, Marco; Martin, Shaun; Pagliarini, Vittoria; Falasca, Laura; Hill, David S; Ellis, Nicola; Al Sabah, Salim; Redfern, Christopher P. F; Fimia, Gian Maria; Piacentini, Mauro; Lovat, Penny E.. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - 17:8(2011), pp. 2216-2226. [10.1158/1078-0432.CCR-10-3003]

Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition

FIMIA, Gian Maria;
2011

Abstract

Metastatic melanoma is characterized by extremely poor survival rates and hence novel therapies are urgently required. The ability of many anticancer drugs to activate autophagy, a lysosomal-mediated catabolic process which usually promotes cell survival, suggests targeting the autophagy pathway may be a novel means to augment therapy.
2011
Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Biphenyl Compounds; Blotting; Western; Boronic Acids; Cell Line; Tumor; Endoplasmic Reticulum; Female; Fenretinide; Humans; Luminescent Proteins; Melanoma; Mice; Microscopy; Fluorescence; Microtubule-Associated Proteins; Nitrophenols; Piperazines; Proto-Oncogene Proteins B-raf; Pyrazines; RNA Interference; Signal Transduction; Sulfonamides; Xenograft Model Antitumor Assays
01 Pubblicazione su rivista::01a Articolo in rivista
Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition / Armstrong, Jane L; Corazzari, Marco; Martin, Shaun; Pagliarini, Vittoria; Falasca, Laura; Hill, David S; Ellis, Nicola; Al Sabah, Salim; Redfern, Christopher P. F; Fimia, Gian Maria; Piacentini, Mauro; Lovat, Penny E.. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - 17:8(2011), pp. 2216-2226. [10.1158/1078-0432.CCR-10-3003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1319182
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