Ever since its discovery in 1991, diazonamide A (1) has been eyed by synthetic chemists as a potential target because of its puzzling molecular architecture and potent biological activity. The race to synthesize this intriguing natural product was further complicated at the end of last year when a synthesis was completed only to prove that the originally proposed structure was in error. The new structural assignment (2) required retooling of synthetic strategies toward the new target. A total synthesis of diazonamide A has now been achieved confirming its newly proposed structure.
Total synthesis of diazonamide A / K. C., Nicolaou; Bella, Marco; Dyk, Chen; Xianhai, Huang; Taotao, Ling; Scott A., Snyder. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 41:18(2002), pp. 3495-3499. [10.1002/1521-3773(20020916)41:18<3495::aid-anie3495>3.0.co;2-7]
Total synthesis of diazonamide A
BELLA, Marco;
2002
Abstract
Ever since its discovery in 1991, diazonamide A (1) has been eyed by synthetic chemists as a potential target because of its puzzling molecular architecture and potent biological activity. The race to synthesize this intriguing natural product was further complicated at the end of last year when a synthesis was completed only to prove that the originally proposed structure was in error. The new structural assignment (2) required retooling of synthetic strategies toward the new target. A total synthesis of diazonamide A has now been achieved confirming its newly proposed structure.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
