Aims: To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT). Methods: A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared. Results: Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p<0.05). Conclusions: The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.
Diffusion-weighted magnetic resonance imaging in patients with prostate cancer treated with radiotherapy / Iannelli, G.; Caivano, R.; Rago, L.; Simeon, V.; Lotumolo, A.; Rabasco, P.; Villonio, A.; Gioioso, M.; Mastrangelo, P.; Barchetti, F.; Panebianco, V.; Macarini, L.; Guglielmi, G.; Cammarota, A.. - In: TUMORI. - ISSN 0300-8916. - 102:1(2016), pp. 71-76. [10.5301/tj.5000415]
Diffusion-weighted magnetic resonance imaging in patients with prostate cancer treated with radiotherapy
Barchetti F.;Panebianco V.;
2016
Abstract
Aims: To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT). Methods: A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared. Results: Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p<0.05). Conclusions: The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.| File | Dimensione | Formato | |
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