The role of fibre intake in the management of patients with pancreatic disease is still controversial. In acute pancreatitis, a prebiotic enriched diet is associated with low rates of pancreatic necrosis infection, hospital stay, systemic inflammatory response syndrome and multiorgan failure. This protective effect seems to be connected with the ability of fibre to stabilise the disturbed intestinal barrier homeostasis and to reduce the infection rate. On the other hand, in patients with exocrine pancreatic insufficiency, a high content fibre diet is associated with an increased wet fecal weight and fecal fat excretion because of the fibre inhibition of pancreatic enzymes. The mechanism by which dietary fibre reduces the pancreatic enzyme activity is still not clear. It seems likely that pancreatic enzymes are absorbed on the fibre surface or entrapped in pectin, a gel-like substance, and are likely inactivated by anti-nutrient compounds present in some foods. The aim of the present review is to highlight the current knowledge on the role of fibre in the nutritional management of patients with pancreatic disorders.

Role of Fibre in Nutritional Management of Pancreatic Diseases / Ribichini, Emanuela; Stigliano, Serena; Rossi, Sara; Zaccari, Piera; Sacchi, MARIA CARLOTTA; Bruno, Giovanni; Badiali, Danilo; Severi, Carola. - In: NUTRIENTS. - ISSN 2072-6643. - (2019). [10.3390/nu11092219]

Role of Fibre in Nutritional Management of Pancreatic Diseases

Emanuela Ribichini;Serena Stigliano;Piera Zaccari;Maria Carlotta Sacchi;Giovanni Bruno;Danilo Badiali;Carola Severi
2019

Abstract

The role of fibre intake in the management of patients with pancreatic disease is still controversial. In acute pancreatitis, a prebiotic enriched diet is associated with low rates of pancreatic necrosis infection, hospital stay, systemic inflammatory response syndrome and multiorgan failure. This protective effect seems to be connected with the ability of fibre to stabilise the disturbed intestinal barrier homeostasis and to reduce the infection rate. On the other hand, in patients with exocrine pancreatic insufficiency, a high content fibre diet is associated with an increased wet fecal weight and fecal fat excretion because of the fibre inhibition of pancreatic enzymes. The mechanism by which dietary fibre reduces the pancreatic enzyme activity is still not clear. It seems likely that pancreatic enzymes are absorbed on the fibre surface or entrapped in pectin, a gel-like substance, and are likely inactivated by anti-nutrient compounds present in some foods. The aim of the present review is to highlight the current knowledge on the role of fibre in the nutritional management of patients with pancreatic disorders.
2019
pancreatitis; pancreatic exocrine insufficiency; nutritional management; maldigestion; diet; fibre
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Role of Fibre in Nutritional Management of Pancreatic Diseases / Ribichini, Emanuela; Stigliano, Serena; Rossi, Sara; Zaccari, Piera; Sacchi, MARIA CARLOTTA; Bruno, Giovanni; Badiali, Danilo; Severi, Carola. - In: NUTRIENTS. - ISSN 2072-6643. - (2019). [10.3390/nu11092219]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1315190
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