ATM mutations in B-cell chronic lymphocytic leukemia

Bullrich, F.; Rasio, Debora; Kitada, S.; Starostik, P.; Kipps, T.; Keating, M.; Albitar, M.; Reed, J. C.; Croce,; Cancer Res Jan, C. M.

Mutations in the ATM gene located on the long arm of chromosome 11 at 11q22-23 cause ataxia-telangiectasia, an autosomal recessive disorder that is associated with increased incidence of malignancy and, particularly, lymphoid tumors. A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of heterozygosity at 11q22-23 and ATM mutations in leukemias carrying TCL-1 rearrangements. Approximately 14% of B-cell chronic lymphocytic leukemia (B-CLL), the most common adult leukemia, carry deletions of the long arm of chromosome 11 at 11q22-23. Loss of heterozygosity at 11q22-23 and, more recently, absence of ATM protein, have been associated with poor prognosis in B-CLL. To determine whether the ATM gene is altered in B-CLL, we have sequenced individual ATM exons in six B-CLL cases. We show that the ATM gene is mutated in a fraction of B-CLLs and that mutations can be present in the germ line of patients, suggesting that ATM heterozygotes may be predisposed to B-CLL.

ATM mutations in B-cell chronic lymphocytic leukemia / F., Bullrich; Rasio, Debora; S., Kitada; P., Starostik; T., Kipps; M., Keating; M., Albitar; J. C., Reed; Croce, ; C. M., Cancer Res Jan. - In: CANCER RESEARCH. - ISSN 0008-5472. - 59:1(1999), pp. 24-27.

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Titolo:	ATM mutations in B-cell chronic lymphocytic leukemia
Autori:	F. Bullrich RASIO, DEBORA S. Kitada P. Starostik T. Kipps M. Keating M. Albitar J. C. Reed Croce C. M. Cancer Res Jan mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1999
Rivista:	CANCER RESEARCH
Citazione:	ATM mutations in B-cell chronic lymphocytic leukemia / F., Bullrich; Rasio, Debora; S., Kitada; P., Starostik; T., Kipps; M., Keating; M., Albitar; J. C., Reed; Croce, ; C. M., Cancer Res Jan. - In: CANCER RESEARCH. - ISSN 0008-5472. - 59:1(1999), pp. 24-27.
Handle:	http://hdl.handle.net/11573/131491
Appartiene alla tipologia:	01a Articolo in rivista

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