Vitamin D is a major regulator of bone and mineral metabolism. However, on the basis of epidemiologic and experimental data numerous extra-skeletal effects are claimed for this vitamin. Indeed, in recent years this vitamin that can be synthesized in the skin, has turned into a true hormone. Moreover, the complexity of synthesis, metabolism and mechanism of action, allow us to identify a sophisticated “vitamin D endocrine system” which includes, besides the active molecule (calcitriol), several specific enzymes of synthesis and degradation, a dedicated plasma transport protein (D binding protein, DBP), a specific receptor (vitamin D receptor or VDR) and some regulating hormones.1 Further to regulation of calcium homeostasis and bone metabolism this system is implicated in extra-skeletal effects through activation of vitamin D receptors (VDR ) in almost every tissue.

Clinical impact of Vitamin D hydroxylation efficiency / Pasquali, M.; Tartaglione, L.; Rotondi, S.; Muci, M. L.; Farcomeni, A.; Marangella, M.; Mazzaferro, S.. - In: MINERVA MEDICA. - ISSN 0026-4806. - 110:3(2019), pp. 259-262. [10.23736/S0026-4806.19.06029-4]

Clinical impact of Vitamin D hydroxylation efficiency

Tartaglione L.
Writing – Original Draft Preparation
;
Rotondi S.
Writing – Original Draft Preparation
;
Muci M. L.
Data Curation
;
Mazzaferro S.
Supervision
2019

Abstract

Vitamin D is a major regulator of bone and mineral metabolism. However, on the basis of epidemiologic and experimental data numerous extra-skeletal effects are claimed for this vitamin. Indeed, in recent years this vitamin that can be synthesized in the skin, has turned into a true hormone. Moreover, the complexity of synthesis, metabolism and mechanism of action, allow us to identify a sophisticated “vitamin D endocrine system” which includes, besides the active molecule (calcitriol), several specific enzymes of synthesis and degradation, a dedicated plasma transport protein (D binding protein, DBP), a specific receptor (vitamin D receptor or VDR) and some regulating hormones.1 Further to regulation of calcium homeostasis and bone metabolism this system is implicated in extra-skeletal effects through activation of vitamin D receptors (VDR ) in almost every tissue.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1314835
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